Clinical Trials in North Carolina

Showing 16521-16540 of 20,428 trials

Multiple-dose Regimen Study to Assess Effect of 12 Months of Secukinumab Treatment on Skin Response and Biomarkers in Psoriasis Patients

NCT01537432

This study is designed to evaluate the proportion of patients achieving reversal of chronic plaque psoriasis at week 4 and 12 following multiple doses of secukinumab administered subcutaneously (sc) compared to placebo. Starting from week 13, all patients will receive multiple doses of secukinumab up to week 52 to study long term effects of secukinumab. Clinical endpoints including biomarker assessments, PASI, IGA and DLQI will be compared to better understand, why secukinumab may be effective in psoriasis patients.

Psoriasis, Plaque-type Psoriasis

Novartis Pharmaceuticals36 participantsStarted Jan 2012

Birmingham, Alabama, United States • Pasadena, California, United States • Indianapolis, Indiana, United States +9 more locations

COMPLETEDPhase 441 miles

A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy

NCT00708201

This study is being conducted to determine whether alvimopan can accelerate recovery of gastrointestinal function following radical cystectomy when compared with a placebo. Secondary objectives of the study are: * to evaluate the effect of alvimopan on hospital length of stay * to evaluate the effect of alvimopan on prespecified postoperative ileus (POI)-related morbidities * to evaluate the overall and cardiovascular safety of alvimopan

Postoperative Ileus

Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)280 participantsStarted Mar 2009

Laguna Hills, California, United States • Aurora, Colorado, United States • Miami, Florida, United States +17 more locations

Multiple-dose Regimen Study to Assess Effect of 12 Months of Secukinumab Treatment on Skin Response and Biomarkers in Psoriasis Patients

A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy

Find Trials by Condition in North Carolina

Safety Study of Apixaban in Recent Acute Coronary Syndrome

Efficacy and Safety Study of Gevokizumab to Treat Behcet's Disease Uveitis

Registry for African Americans With Early Rheumatoid Arthritis

A Study in Men With Low Testosterone to Measure the Effects of Testosterone Solution on Testosterone Levels, Sex Drive and Energy

Expanded Treatment Prot of Panobinostat in Combo w/ Bortez and Dex in Pts w/ Relapsed and/or Refractory Multiple Myeloma

Safety, Pharmacokinetics, and Pharmacodynamics of NBI-98854 in Children and Adolescents With Tourette Syndrome

Safety and Efficacy Study of an Anti-CD20 Monoclonal Antibody (AME-133v) to Treat Non-Hodgkin's Lymphoma

Guidant Microwave Ablation System for the Treatment of Atrial Fibrillation

Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell Transplantation

Safety and Antiviral Study of ACH-126, 443 (Beta-L-Fd4C) in the Treatment of Adults With HIV Infection and Modestly Detectable Viral Load.

A MultiCenter Study of Combined PEX, Rituximab, and Steroids in Acute Idiopathic Pulmonary Fibrosis Exacerbations

Study Evaluating ACC-001 In Subjects With Mild To Moderate Alzheimer's Disease

Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Noninvasive Methods to Monitor Graft Survival in Heart Transplant Patients

HT-0712 vs. Placebo in Subjects With Age-Associated Memory Impairment (AAMI)

Coordinating Center for Caregiver Intervention Trial

Imexon for Relapsed Follicular and Aggressive Lymphomas

A Pharmacodynamics Pre-surgical Study of LEE011 in Early Breast Cancer Patients (MONALEESA-1)