Clinical Trials in North Carolina

Showing 12261-12280 of 20,428 trials

Ultrafiltration Profiling and Outcomes Among Individuals on Maintenance Hemodialysis

NCT03301740

The rate of fluid removal (ultrafiltration, UF) during hemodialysis (HD) may contribute to cardiovascular morbidity and mortality among individuals receiving maintenance HD. More rapid UF rates are associated with higher morbidity and mortality. Ultrafiltration profiling, the practice of varying UF rates to maximize fluid removal during periods of greatest hydration and plasma oncotic pressures, is one treatment modification that may reduce UF-related harm without necessitating reduction in interdialytic fluid intake or longer HD treatments. To date, UF profiling has not been adequately studied independent of sodium profiling. This study investigates the comparative effect of UF profiling versus non-profiled conventional HD on select cardiovascular and patient-reported outcomes. Participants will complete two phases of UF profiling and two phases of conventional HD and will act as their own controls.

End Stage Renal Disease

University of North Carolina, Chapel Hill34 participantsStarted Mar 2018

Carrboro, North Carolina, United States • Siler City, North Carolina, United States

COMPLETEDPhase 341 miles

Nortriptyline for Idiopathic Gastroparesis

NCT00765895

The principal objective of this multicenter, randomized, placebo-controlled trial is to evaluate whether treatment with nortriptyline will improve gastroparesis symptoms compared with placebo.

Idiopathic Gastroparesis

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)130 participantsStarted Jan 2009

San Francisco, California, United States • Stanford, California, United States • Ann Arbor, Michigan, United States +4 more locations

Ultrafiltration Profiling and Outcomes Among Individuals on Maintenance Hemodialysis

Nortriptyline for Idiopathic Gastroparesis

Find Trials by Condition in North Carolina

Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant

Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia

A Study of the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Moderate to Severe Plaque Psoriasis of the Scalp

Safety and Efficacy Study of Apremilast to Treat Psoriatic Arthritis

Study to Evaluate the Safety and Efficacy of Filgotinib and Lanraplenib in Adults With Lupus Membranous Nephropathy (LMN)

Effect of Cross Frequency tACS on Cognitive Control

H.O.P.E: Helping Ovarian Cancer Patients Cope

Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Effectiveness

Study of Vicinium for Treating Patients With Non-Invasive Urothelial Carcinoma In Situ

To Assess the Safety and Activity of GBR 830, Compared to Placebo, in Adults With Moderate-to-severe Atopic Dermatitis

Study to Evaluate the Efficacy of Etanercept Treatment in Adults Who Failed Therapy With Apremilast

Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies

Study of Carboplatin/Paclitaxel With or Without Investigational Drug (CS-7017) in Subjects With Metastatic Non-small Cell Lung Cancer

Study of Apremilast to Treat Subjects With Active Ankylosing Spondylitis

Iloprost in Preventing Lung Cancer in Patients at High Risk for This Disease

Study of Ataluren in Nonsense Mutation Cystic Fibrosis (ACT CF)

Long-Term Safety Study of Buprenorphine (CAM2038) in Adult Outpatients With Opioid Use Disorder

Extension Study of BIIB092 in Participants With Progressive Supranuclear Palsy (PSP) Who Participated in CN002003