Clinical Trials in North Carolina

Showing 8141-8160 of 20,428 trials

Developmental Impact of NICU Exposures (DINE)

NCT03061890

The DINE study will test the hypothesis that potentially avoidable NICU-based exposures contribute to the neuro-cognitive and somatic impairments prevalent among NICU graduates. This hypothesis is drawn from the documented impact of phthalate exposure on early development in term-born children, and the acknowledged presence of these toxic chemicals in the NICU. Third trimester in utero exposure to phthalates have been linked to poorer childhood performance in cognition, motor function, attention, hyperactivity and social behavior. Phthalate exposure is also associated with altered onset of puberty and asthma. The multi-site cohort and approach will clarify the role of NICU-based phthalate exposure on high-prevalence clinical outcomes.

Prematurity

Albert Einstein College of Medicine600 participantsStarted Apr 2017

Jacksonville, Florida, United States • Boston, Massachusetts, United States • Minneapolis, Minnesota, United States +8 more locations

COMPLETEDPhase 341 miles

ROMAN: Phase 3 Trial Investigating the Effects of GC4419 on Radiation Induced Oral Mucositis in Head/Neck Cancer Patients

NCT03689712

The purpose of the phase 3, clinical study is to determine if GC4419 (avasopasem manganese) administered prior to intensity-modulated radiation therapy (IMRT) reduces the severity of radiation induced oral mucositis in patients who have been diagnosed with locally advanced, non-metastatic squamous cell carcinoma of the head and neck.

Oral Mucositis

Galera Therapeutics, Inc.455 participantsStarted Oct 2018

Gilbert, Arizona, United States • Jonesboro, Arkansas, United States • Corona, California, United States +94 more locations

Developmental Impact of NICU Exposures (DINE)

ROMAN: Phase 3 Trial Investigating the Effects of GC4419 on Radiation Induced Oral Mucositis in Head/Neck Cancer Patients

Find Trials by Condition in North Carolina

A Prospective Study to Evaluate the ConforMIS iTotal® (PS) Knee Replacement System

Dinutuximab in Combination With Sargramostim in Treating Patients With Recurrent Osteosarcoma

Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With HR+ HER2- aBC

Alignment Comparison Between TruMatch™ Personalized Solutions and Conventional Total Knee Replacement Instrumentation

Evaluating the Analytical Equivalency of Serum and Whole Blood Samples Run on the MeMed Key® Platform (Perseverance Study)

Volume Optimization Incorporating Negative Pressure Diuresis in Heart Failure (VOID-HF)

A Study to Evaluate the Conformis Hip System

Identification of Clinically Insignificant or Significant Prostate Cancer With the miR Scientific Sentinel™ Platform

A Study to Investigate Atezolizumab and Chemotherapy Compared With Placebo and Chemotherapy in the Neoadjuvant Setting in Participants With Early Stage Triple Negative Breast Cancer

Multi-Center Study to Evaluate the ConforMIS iUni Knee Implant

A Study of HB0045 Injection in Patients With Advanced Solid Tumors

Sintilimab or Placebo With Chemotherapy in Esophageal Squamous Cell Carcinoma ( ORIENT-15 )

APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma

A Retrospective Study of the iTotal CR Knee Replacement System

A Study to Evaluate the Conformis iTotal Identity Knee Replacement System

A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System

Study of the ConforMIS iDuo(R) G2

A Study to Evaluate the Effect of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Sitravatinib