Clinical Trials in North Carolina

Showing 5921-5940 of 20,428 trials

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

NCT02827838

This pilot clinical trial studies how well durvalumab before surgery works in treating patients with oral cavity or oropharynx cancer. Monoclonal antibodies, such as durvalumab, may interfere with the ability of tumor cells to grow and spread.

Human Papillomavirus InfectionStage I Oral Cavity Squamous Cell CarcinomaStage I Oropharyngeal Squamous Cell Carcinoma+9 more

Wake Forest University Health Sciences17 participantsStarted Jan 2017

Winston-Salem, North Carolina, United States

COMPLETEDPhase 341 miles

Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer

NCT02492711

The purpose of this study is to determine whether patients with metastatic breast cancer treated with margetuximab plus chemotherapy have longer progression free survival (PFS) and overall survival (OS) than patients treated with trastuzumab plus chemotherapy. A non-randomized sub-study cohort of approximately 88 patients will be enrolled to evaluate the safety of a reduced margetuximab infusion rate in patients receiving margetuximab either as monotherapy or in combination with chemotherapy.

HER-2 Positive Breast CancerMetastatic Neoplasm

MacroGenics624 participantsStarted Aug 2015

Chandler, Arizona, United States • Gilbert, Arizona, United States • Goodyear, Arizona, United States +164 more locations

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer

Find Trials by Condition in North Carolina

Study of KeraStat Cream for Radiation Dermatitis During Head and Neck Radiotherapy

A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism

A Study Evaluating the Safety and Efficacy of Lovo-cel in Severe Sickle Cell Disease

Open-Label Study to Evaluate Safety and Efficacy of CCX168 in Subjects With IGA Nephropathy on Stable RAAS Blockade

Clinical Trial to Evaluate Safety and Efficacy of CCX168 in ANCA-Associated Vasculitis

A Study of Etigilimab and Nivolumab in Participants With Locally Advanced or Metastatic Tumors

A Study of INCB050465 in Relapsed or Refractory Follicular Lymphoma

Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study

Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)

AGEN1884, an Anti-CTLA-4 Human Monoclonal Antibody in Participants With Advanced or Refractory Cancer and Who Have Progressed With PD-1/PD-L1 Inhibitor as Their Most Recent Therapy

p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

A Study of LY3561774 in Participants With Mixed Dyslipidemia

Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: the VAPOR-C Trial

A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure

A Post Market Device Study for the Treatment of Acne

Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function

Angio-IMR and Cardiac MR-derived MVO in STEMI Patients

Pivotal, Clinical Study for the Accuracy Evaluation of the IdentiClone Dx TRG Assay