Clinical Trials in New York

Showing 6061-6080 of 22,668 trials

Mitochondrial Stress, Brain Imaging, and Epigenetics

NCT04831424

The MiSBIE study collects biological, behavioral, psychosocial, neuropsychological, and brain imaging data in participants with either: normal mitochondrial function, individuals with the m.3243A\>G mitochondrial DNA (mtDNA) mutation, and individuals a single large-scale mtDNA deletion. These defects induce mitochondrial allostatic load (MAL). The 2-day protocol, plus home-based data collection, will provide a comprehensive assessment of the multi-systemic dysregulation associated with MAL or mitochondrial dysfunction, and the link to physical and mental health-related symptoms. Aim 1: Determine the influence of MAL on systemic AL biomarkers. Aim 2: Establish the influence of MAL on stress reactivity profiles. Aim 3. Examine the association between MAL and psychological functioning.

Mitochondrial Diseases

Columbia University110 participantsStarted Jun 2018

New York, New York, United States

RECRUITINGPhase 1< 1 mile

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

NCT06371417

This Phase 1b basket trial will investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary efficacy of RAY121, a inhibitor of classical complement pathway, after multiple dose administration in patients with immunological diseases such as antiphospholipid syndrome (APS), bullous pemphigoid (BP), Behçet's Syndrome (BS), dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM) and immune thrombocytopenia (ITP).

Antiphospholipid Syndrome (APS)Bullous Pemphigoid (BP)Behçet's Syndrome (BS)+3 more

Chugai Pharmaceutical144 participantsStarted Aug 2024

Orange, California, United States • Baltimore, Maryland, United States • Lake Success, New York, United States +64 more locations

Mitochondrial Stress, Brain Imaging, and Epigenetics

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

Find Trials by Condition in New York

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Clinical Trial of Approaches to Prostate Cancer Surgery

A Second Intermediate-Size Expanded Access Protocol (EAP) for Pridopidine in People With Amyotrophic Lateral Sclerosis (Pridopidine EAP 2)

Study of Safety and Efficacy of Novel Immunotherapy Combinations in Patients With Triple Negative Breast Cancer (TNBC).

A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer

A Study to Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age

An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation

Engaging Patients to Promote Deprescribing

PRimary Care Opioid Use Disorders Treatment (PROUD) Trial

SURPASS Impella 5.5 Study

StimRouter Registry Clinical Protocol

Study to Assess the Immune Response, the Safety and the Reactogenicity of Respiratory Syncytial Virus (RSV) Prefusion Protein 3 Older Adult (OA) (RSVPreF3 OA) Investigational Vaccine When co Administered With PCV20 in Older Adults

Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Adolescent Males

A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease

Stopping Aminosalicylate Therapy in Inactive Crohn's Disease

RecruitmEnt Assessed by eleCtRical Impedance Tomography

A Retrospective Chart Review Study of Patients With Chronic Lung Allograft Dysfunction-Bronchiolitis Obliterans Syndrome (CLAD-BOS) Post Lung Transplantation

Digital Support Systems to Improve Child Health and Development in Peru