Clinical Trials in New York State

Showing 3161-3180 of 14,718 trials

Comparing Hypothermic Temperatures During Hemiarch Surgery

NCT02860364

Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer core body temperatures during circulatory arrest has emerged. This trial will randomize patients to either mild (32°C) or moderate (26°C) hypothermia during aortic hemiarch surgery to determine if mild hypothermia reduces the length of cardiopulmonary bypass time and other key measures of morbidity and mortality.

Thoracic Aortic Disease

Ottawa Heart Institute Research Corporation282 participantsStarted Feb 2018

Boston, Massachusetts, United States • Ridgewood, New Jersey, United States • Columbus, Ohio, United States +9 more locations

COMPLETEDPhase 397 miles

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

NCT03525574

The study evaluates the long-term safety and tolerability of VX-445 in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are homozygous or heterozygous for the F508del mutation

Cystic Fibrosis

Vertex Pharmaceuticals Incorporated507 participantsStarted Oct 2018

Tucson, Arizona, United States • Little Rock, Arkansas, United States • Long Beach, California, United States +107 more locations

Comparing Hypothermic Temperatures During Hemiarch Surgery

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Find Trials by Condition in New York State

Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

Study of Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) in Prevention of HIV in Cisgender Women in the United States (HPTN 102)

Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2

Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma

Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (TouCAHn)

Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

A Study of STRO-002, an Anti-Folate Receptor Alpha Antibody Drug Conjugate, in Combination With Bevacizumab in Epithelial Ovarian Cancer

Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients

Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial

A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Acne Vulgaris

Phase 2 Safety and Efficacy Evaluation of AL8326 in ≥2nd Line SCLC

An Extension Study to Evaluate Safety and Efficacy in Participants Treated With CRN04894

Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors