Clinical Trials in Nashville

Showing 141-160 of 17,403 trials

Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer

NCT07558733

The study is a Phase 1b/2, multi-center, open-label, dose escalation trial evaluating the safety and preliminary efficacy of sapanisertib and serabelisib (PIKTOR) with fulvestrant and/or other anticancer therapies in participants with HR+/HER2- advanced/metastatic breast cancer.

HR+ HER2- Breast Cancer

Faeth Therapeutics32 participantsStarted Apr 2026

Los Angeles, California, United States • Springfield, Oregon, United States • Nashville, Tennessee, United States

Active Not RecruitingPhase 2< 1 mile

Theophylline Treatment for Pseudohypoparathyroidism

NCT03029429

Pseudohypoparathyroidism is a genetic disorder with limited treatment options. Patients have early-onset obesity, short stature and increased risk of type 2 diabetes. This phase 2 clinical trial will test the efficacy of theophylline, a phosphodiesterase inhibitor, in pseudohypoparathyroidism. The investigators hypothesize that theophylline will cause weight loss, improve glucose tolerance and slow growth plate closure in children and young adults.

PseudohypoparathyroidismAlbright Hereditary Osteodystrophy

Vanderbilt University Medical Center29 participantsStarted Sep 2018

Nashville, Tennessee, United States

RECRUITINGPhase 3< 1 mile

VE303 for Prevention of Recurrent Clostridioides Difficile Infection

NCT06237452

The overall objective of the RESTORATiVE303 study is to evaluate the safety and the Clostridioides difficile infection (CDI) recurrence rate at Week 8 in participants who receive a 14-day course of VE303 or matching placebo. The objectives and endpoints are identical for Stage 1 (recurrent CDI) and Stage 2 (high-risk primary CDI).

Clostridium DifficileClostridium Difficile InfectionsClostridium Difficile Infection Recurrence+7 more

Vedanta Biosciences, Inc.852 participantsStarted May 2024

Huntsville, Alabama, United States • Chandler, Arizona, United States • Phoenix, Arizona, United States +212 more locations

Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer

Theophylline Treatment for Pseudohypoparathyroidism

VE303 for Prevention of Recurrent Clostridioides Difficile Infection

Find Trials by Condition in Nashville

Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR)

Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

Efficacy and Safety of Seralutinib in Adult Subjects With PAH (PROSERA)

Testing Radiation and HER2-targeted Therapy Versus HER2-targeted Therapy Alone for Low-risk HER2-positive Breast Cancer

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations

The PROMISE Pediatric Study 6 to 11 Years Old

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma

Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery

A Study to Learn More About the Long-Term Safety and Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Antibody-Mediated Rejection (AMR)