Clinical Trials in Michigan

Showing 4561-4580 of 16,154 trials

Safety, Tolerability, PK/PD & Preliminary Efficacy of SKL27969 in Advanced Solid Tumors Patients

NCT05388435

Primary Objective of Part 1 (Dose Escalation Phase): Evaluate the safety and tolerability of SKL27969, and determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of SKL27969 Primary Objective of Part 2 (Dose Expansion Phase): Evaluate the preliminary anti-tumor activity of SKL27969

Advanced Solid Tumor

SK Life Science, Inc.15 participantsStarted Sep 2022

Duarte, California, United States • Grand Rapids, Michigan, United States • Huntersville, North Carolina, United States +1 more locations

COMPLETEDPhase 383 miles

HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patients

NCT03569891

This is an open-label, single-dose, multi-center, multinational trial to demonstrate the efficacy of AMT-061 and to further describe its safety profile. The study drug is identified as AAV5-hFIXco-Padua (AMT- 061). AMT-061 is a recombinant adeno-associated viral vector of serotype 5 (AAV5) containing the Padua variant of a codon-optimized human FIX complementary deoxyribonucleic acid (cDNA) under the control of a liver-specific promoter. The pharmaceutical form of AMT-061 is a solution for intravenous infusion administered at a dose of 2 x 10\^13 gc/kg.

Hemophilia B

CSL Behring67 participantsStarted Jun 2018

Phoenix, Arizona, United States • Little Rock, Arkansas, United States • Los Angeles, California, United States +30 more locations

Safety, Tolerability, PK/PD & Preliminary Efficacy of SKL27969 in Advanced Solid Tumors Patients

HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patients

Find Trials by Condition in Michigan

AltaValve Pivotal Trial

Safe and Timely Antithrombotic Removal - Direct Oral Anticoagulants Apixaban & Rivaroxaban (STAR-D)

A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

A Phase III, Crossover Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)

L-DOS47 Plus Doxorubicin in Advanced Pancreatic Cancer

KIR Favorable Mismatched Haplo Transplant and KIR Polymorphism in ALL/AML/MDS Allo-HCT Children

A Study to Evaluate the enVista® Aspire (EA) Intraocular Lens in Subjects Undergoing Cataract Extraction

Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products

A Study of PF-07260437 in Advanced or Metastatic Solid Tumors

Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease

Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas

Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:

An Observational Study to Validate the Cumulative Life Course Impairment (CLCI) Instrument (DermCLCI-p) in Adult Participants With Moderate to Severe Chronic Plaque Psoriasis (PsO)

Log2Lose: Incenting Weight Loss and Dietary Self-monitoring in Real-time to Improve Weight Management Among Adults With Obesity

Extended Treatment and Follow-up of Subjects Treated With Belumosudil in Study KD025-208 or Study KD025-213

A Study to Investigate How Respiratory Syncytial Virus (RSV) Infection Develops and Changes Over Time in Pediatric Participants

Retrospective Clinical Trial Comparing Radiologists' Diagnosis Accuracy in Lung Cancer Screening Population With and Without the Help of an AI/ML Tech-based SaMD