Clinical Trials in Massachusetts

Showing 1681-1700 of 15,316 trials

Long-term Safety and Efficacy of Leniolisib in PIDs With Immune Dysregulation

NCT06990529

This is an open-label extension (OLE) study to extend treatment to patients with primary immunodeficiency (PID) disorders linked to phosphoinositide 3-kinase delta signaling who participated in a prior study of leniolisib, LE 7201. The primary objective is to assess long-term safety and tolerability of leniolisib. Secondary and exploratory objectives include various efficacy and immunophenotyping measures for leniolisib.

PIDs Linked to PI3K

Pharming Technologies B.V.12 participantsStarted Apr 2025

Bethesda, Maryland, United States • Burlington, Massachusetts, United States • New York, New York, United States +1 more locations

RECRUITINGPhase 326 miles

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

NCT06712355

This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).

Extensive-stage Small-cell Lung Cancer

BioNTech SE621 participantsStarted Feb 2025

Clermont, Florida, United States • Palm Bay, Florida, United States • Niles, Illinois, United States +135 more locations

Long-term Safety and Efficacy of Leniolisib in PIDs With Immune Dysregulation

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

Find Trials by Condition in Massachusetts

TIL Therapy in cSCC and MCC

Single Use Bronchoscopes for Interventional Pulmonology

Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants With Myotonic Dystrophy Type 1

Supporting Our Caregivers In ADRD Learning (SOCIAL)

Eliminating Monitor Overuse Trial (EMO Trial)

Study to Assess Safety, Efficacy and Persistence of ACE1831, in Subjects With IgG4-Related Disease

A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy

Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Study of Bitopertin in Participants With EPP or XLP (APOLLO)

A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry

Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System

A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)

SPI-62 as a Treatment for Hypercortisolism Related to a Benign Adrenal Tumor

Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment