Clinical Trials in Massachusetts

Showing 1981-2000 of 15,316 trials

Feasibility of the Comfort Measures Only Time Out (CMOT)

NCT05861323

Nearly 25% of Americans die in intensive care units (ICUs). Most deaths in ICUs are expected and involve the removal of ventilator support, or palliative withdrawal of mechanical ventilation (WMV). Prior work by the Principal Investigator (PI) found that patient suffering can be common; with 30-59% of patients going through this process experiencing distress. Thus, experts and national organizations have called for evidence to inform guidelines for WMV. This research study will 1) develop and refine a Comfort Measures Only Time out (CMOT) intervention consisting of a structured time out with check-list protocol for the ICU team (nurse, physician, respiratory therapist) to improve the process of WMV. and 2) Pilot test the CMOT intervention in 4 ICUs (2 medical/2 surgical) among 40 WMV patients.

End of LifeRespiratory FailureVentilatory Failure+2 more

Beth Israel Deaconess Medical Center184 participantsStarted Oct 2023

Boston, Massachusetts, United States

RECRUITING26 miles

PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery

NCT06089083

This study seeks to understand how frailty, a term that describes people who are more vulnerable stressors such as a new medical problem, affects the outcomes and quality of life in adult patients with gynecologic cancer.

Malignant Female Reproductive System NeoplasmGynecologic CancerGynecologic Neoplasm

University of California, San Francisco500 participantsStarted Oct 2023

San Francisco, California, United States • Boston, Massachusetts, United States

Feasibility of the Comfort Measures Only Time Out (CMOT)

PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery

Find Trials by Condition in Massachusetts

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

A Study of Abemaciclib (LY2835219) in Participants With Non-Small Cell Lung Cancer or Breast Cancer

Evaluating the Role of Inflammation in Neonatal Epileptogenesis

Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer

Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury

Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect

Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)

Academic Detailing to Optimize PrEP Implementation in Pediatric Primary Care Settings: ADOPT-PrEP

Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study

PIONEER III Trial to Assess Safety and Efficacy of the BuMA Supreme™ Drug Coated Coronary Stent in Patients With Coronary Disease

Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

First-in-Human Study of ICT01 in Patients With Advanced Cancer

This Study Tests the New Medicine BI 754111 Alone or in Combination With Another New Substance BI 754091 in Patients With Advanced Cancer. The Study Tests Different Doses to Find the Best Dose for Continuous Treatment.

Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction

Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks

Study to Evaluate Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-291 Moves Through the Body in Adult Participants With Non-Hodgkin's Lymphoma