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Discover 23,284 clinical trials near Maryland. Find research studies in your area.
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NCT00546091
This study will explore the uses of three noninvasive imaging techniques-thermography, laser Doppler imaging, and multispectral imaging-to test the blood flow of healthy volunteers. By comparing these three techniques, researchers will be able to train these imaging systems to better evaluate skin types and blood flow. The study will also test computer programs that have been developed to correct for the effects of curvature and body hair on the images. Healthy volunteers must be older than 18 years of age and may not have had a history of malignant tumors, skin disease, or vascular disease. Participants will undergo the following procedures on an outpatient basis: Three different types of images taken of the participant s forearm * Thermography infrared thermal imaging to map skin temperature * Laser Doppler imaging low-powered laser imaging to map blood flow in the skin * Multispectral imaging near-infrared light imaging to measure total blood flow and oxygen levels in the skin A reactive hyperemia experiment, in which multispectral images will be taken of the participant s forearm during and after the use of a blood pressure cuff A hair removal experiment, in which images will be collected of the participant s forearm in separate scans done before and after the hair is removed with a topical hair removal solution The entire series of exams will take approximately one hour to perform.
NCT00955864
Background: * The uterine cervix is composed of muscle and collagen, which change as women age and under hormonal influences like puberty, pregnancy, and menopause. Yet even though knowledge of structure of the cervix (especially the collagen network) is important to detect problems that may affect pregnancy and other women s health issues, no noninvasive techniques are available to evaluate such changes. * A specially designed polarized camera attached to a conventional colposcope can be used to take cervical images. Analyzing these images may enable researchers to better visualize the collagen network in the cervix. Objectives: * To explore and gain experience with the use of a polarized imaging system to study cervical structure. * To evaluate the usefulness of a polarized imaging system in studying the cervical structure of healthy nonpregnant women. Eligibility: \- Adult females (at least 18 years of age) who are having regular menstrual cycles and are not on hormonal medications. Design: * Images will be takes from the cervix in two different phases of menstruation cycle time, one in the follicular phase (before ovulation) and another one in the luteal phase (after ovulation). * The images of the cervix will be taken with a vaginal speculum in place with the camera attached to a colposcope. The colposcope will illuminate the cervix using polarized light. Three random cervical locations will be photographed