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Discover 23,284 clinical trials near Maryland. Find research studies in your area.
Showing 13481-13500 of 23,284 trials
NCT02118012
Background: \- Hepatitis C is a liver disease caused by the hepatitis C virus. It is the most common cause of serious liver disease in the United States. Many people have few if any symptoms. It can lead to cirrhosis, which can cause liver failure and cancer. Researchers want to study how a medicine called chlorcyclizine works in patients with hepatitis C. They want to see if it can be used to treat hepatitis C alone or when used with the standard hepatitis C treatment drug ribavirin. Objectives: \- To see if chlorcyclizine can be used to treat hepatitis C alone or in combination with the drug ribavirin. Eligibility: \- Adults with chronic hepatitis C who either have never been treated for it or have relapsed after prior treatment. Design: * Participants will be screened with medical history, physical exam, blood and urine tests, and a questionnaire. They will also have an ultrasound of their abdomen and electrocardiogram. Some of these tests will be repeated throughout the study. * Participants will spend 3 days as an inpatient to be monitored while starting study drug. They will be assigned randomly to a group and will begin taking the study drug. Blood will be taken frequently. * Group I will take the study drug twice a day for 28 days. * Group II will take the study drug twice a day and ribavirin twice a day for 28 days. * Participants will visit the clinic every 7 days for 28 days. * After participants stop taking the study drug, they will have 5 follow-up visits over 3 months.
NCT03354637
Primary: • To assess safety, tolerability and efficacy of 2 dose strengths of ATI-50002 Topical Solution, compared to vehicle in subjects with alopecia areata (AA) Secondary: • To evaluate key clinical outcome assessments