Clinical Trials in Maryland

Showing 10361-10380 of 23,284 trials

Assessment of Safety, Tolerability, Immunogenicity, and Pharmacokinetics of AZD3427

NCT04630067

This first-time-in-human (FTIH) study will be conducted to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of single doses of AZD3427 in healthy volunteers and multiple doses of AZD3427 in patients with heart failure (HF).

Heart Failure

AstraZeneca105 participantsStarted Nov 2020

Little Rock, Arkansas, United States • Glendale, California, United States • Daytona Beach, Florida, United States +7 more locations

COMPLETEDPhase 217 miles

Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma

NCT01767194

This randomized phase II trial studies how well irinotecan hydrochloride and temozolomide with temsirolimus or dinutuximab work in treating younger patients with neuroblastoma that has returned or does not respond to treatment. Drugs used in chemotherapy, such as irinotecan hydrochloride and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as dinutuximab, may find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether giving irinotecan hydrochloride and temozolomide together with temsirolimus or dinutuximab is more effective in treating neuroblastoma.

GanglioneuroblastomaRecurrent Neuroblastoma

National Cancer Institute (NCI)73 participantsStarted Feb 2013

Phoenix, Arizona, United States • Little Rock, Arkansas, United States • Little Rock, Arkansas, United States +154 more locations

Assessment of Safety, Tolerability, Immunogenicity, and Pharmacokinetics of AZD3427

Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma

Find Trials by Condition in Maryland

Diarrhea Prevention and Prophylaxis With Crofelemer in HER2 Positive Breast Cancer Patients

Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer

K0706 for Patients Diagnosed With Dementia With Lewy Bodies

Absorption, Metabolism, and Excretion Study of [14C]-TNP-2092

Primary Tube Versus Trabeculectomy Study

Multicenter Endoscopic Sleeve Gastrectomy (ESG) Trial (MERIT Trial)

Time and Motion Study for Ocrelizumab and Ofatumumab Administration in Relapsing Multiple Sclerosis

S1505: Combination Chemotherapy or Gemcitabine Hydrochloride and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery

Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma

Multicenter Study Of Natalizumab Plus Standard Steroid Treatment For High Risk Acute Graft-Versus-Host Disease

The Smart Pump Study

Sunstone IPL (Intense Pulsed Light) for Hair Reduction

Non-Interventional Post-Marketing Safety Study on the Long-Term Safety of HYQVIA (Global)

A Single and Multiple Ascending Dose Trial of KT-474 in Healthy Adult Volunteers and Patients With Atopic Dermatitis (AD) or Hidradenitis Suppurativa (HS)

Study of Dapivirine Vaginal Ring (VR) in Adolescents

Engaging Moms on Teen Indoor Tanning Through Social Media

Therapy for Pediatric Hodgkin Lymphoma

A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients With PNH