Clinical Trials in Maryland

Showing 8661-8680 of 23,284 trials

PRT1419 as Monotherapy or in Combination With Azacitidine or Venetoclax in R/R Myeloid or B-cell Malignancies

NCT05107856

This is a Phase 1 dose-escalation study of PRT1419, a myeloid cell leukemia-1 (MCL-1) inhibitor, in participants with selected relapsed/refractory myeloid or B-cell malignancies. The purpose of this study is to evaluate the safety and tolerability of PRT1419 monotherapy and in combination with either azacitidine or venetoclax, describe any dose limiting toxicities (DLTs), define the dosing schedule, and to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D).

Acute Myeloid LeukemiaB-cell Non-Hodgkin LymphomaChronic Lymphocytic Leukemia+7 more

Prelude Therapeutics21 participantsStarted Mar 2022

Orange City, Florida, United States • Orlando, Florida, United States • Bethesda, Maryland, United States +6 more locations

TERMINATEDPhase 317 miles

OSE2101 Versus Chemotherapy in HLA-A2 Positive Patients With Advanced NSCLC After Immune Checkpoint Inhibitor Failure

NCT02654587

The aim of this clinical trial was to determine if the therapeutic cancer vaccine OSE2101 (TEDOPI) was more effective than standard chemotherapy (docetaxel or pemetrexed) in treating HLA-A2 positive patients with metastatic NSCLC who progressed after sequential or concurrent chemotherapy and immune checkpoint inhibitor given in first or second-line treatment. The main questions were to compare the survival, the tolerance to treatment and the quality of life of patients between the two arms of treatment (OSE2101 versus standard chemotherapy)

Non Small Cell Lung Cancer

OSE Immunotherapeutics219 participantsStarted Feb 2016

Burbank, California, United States • Washington D.C., District of Columbia, United States • Boca Raton, Florida, United States +75 more locations

PRT1419 as Monotherapy or in Combination With Azacitidine or Venetoclax in R/R Myeloid or B-cell Malignancies

OSE2101 Versus Chemotherapy in HLA-A2 Positive Patients With Advanced NSCLC After Immune Checkpoint Inhibitor Failure

Find Trials by Condition in Maryland

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

tDCS in Pediatric Acquired Brain Injury

EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)

STAT: Standard Therapy Plus Active Therapy

Tracheostomy Robotics and Cutting-edge Health Education for Airway Safety

ILLUMENATE Pivotal Post-Approval Study (PAS)

Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)

Study in Subjects With Small Primary Choroidal Melanoma

A Study of Melphalan Flufenamide (Melflufen)-Dex or Pomalidomide-dex for RRMM Patients Refractory to Lenalidomide

Evaluation of Real-World Data on the Performance of the TECNIS Odyssey™ IOL

The Acute Burn ResUscitation Multicenter Prospective Trial

Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris

Ascertaining the Radiologic Prognostic Importance of Extranodal Extension on Imaging (iENE) in Head and Neck Cancer

A Study of mRNA-1020 and mRNA-1030 Seasonal Influenza Vaccines in Healthy Adults

Nu-3 Topical Gel for Treatment of Diabetic Foot Ulcer

A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01)

Optimizing Video Communication Assessment for Teaching Error Disclosure Skills

Efficacy, Safety, and Tolerability of ATM-AVI in the Treatment of Serious Infection Due to MBL-producing Gram-negative Bacteria