Clinical Trials in Los Angeles

Showing 6881-6900 of 16,901 trials

A Novel Human Lab Model for Screening AUD Medications

NCT04249882

This study design consists of a randomized, double-blind, placebo-controlled, 3-arm, parallel-group study of naltrexone (50 mg QD) and varenicline (1 mg BID). A total of 108 men and women with current AUD (moderate or severe) and reporting intrinsic motivation to change their drinking, will be randomly assigned to receive naltrexone (50 mg QD), varenicline (1 mg BID) or matched placebo. Post-randomization, all participants will complete an alcohol cue-reactivity paradigm prior to the initial dose of study medication. After a week-long medication titration period, participants will be asked to complete a 7-day practice quit attempt, during which they will have daily virtual visits (phone and online) where they will report on their alcohol use. Additionally, a second cue-reactivity paradigm will be conducted 90 minutes following study drug administration on final day of the practice quit attempt (Day 14).

Alcohol Use Disorder

University of California, Los Angeles53 participantsStarted Jan 2020

Los Angeles, California, United States

COMPLETEDPhase 37.0 miles

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

NCT00709865

The purpose of the current study is to assess the safety and tolerability of intravenous tonapofylline.

Renal InsufficiencyCongestive Heart Failure

Biogen420 participantsStarted Jul 2008

Huntsville, Alabama, United States • Mobile, Alabama, United States • Fort Smith, Arkansas, United States +186 more locations

A Novel Human Lab Model for Screening AUD Medications

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

Find Trials by Condition in Los Angeles

Study of Sotatercept for the Treatment of Chemotherapy Induced Anemia in Patients With Metastatic Breast Cancer (MK-7962-012)

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647

Addressing Dementia Via Agitation-Centered Evaluation

A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens

Real World Evaluation of the Effectiveness of AZD7442 for Prevention of SARS-CoV-2

Consolidation Pembrolizumab Following Chemoradiation in Patients With Inoperable/Unresectable Stage III NSCLC

PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct Cancer

Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

Dynamic Vision Testing and Concussion Management

A Comparison of Dynamic Vision & Balance Between College Athletes & Controls

Study of the Safety and Efficacy of PRX-102 Compared to Agalsidase Beta on Renal Function

Efficacy and Safety of Orally Administered BBT-401-1S in Subjects With Ulcerative Colitis

Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis

Impact of Acetaminophen on Performance of Guardian™ Sensor (3) in Adults

Dociparstat Sodium (CX-01) Combined With Standard Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia

Study of Ipatasertib or Apitolisib With Abiraterone Acetate Versus Abiraterone Acetate in Participants With Castration-Resistant Prostate Cancer Previously Treated With Docetaxel Chemotherapy

Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy