Clinical Trials in Houston

Showing 8981-9000 of 17,885 trials

Electrophysiological Biomarkers of AV-101

NCT03583554

Suicide is 2-7x higher in Veterans than non-veterans, and may be related to brain kynurenine pathway (KP) dysregulation and NMDA receptor (NMDAR) hyperactivation. Experimental drug "AV-101" modulates the brain KP, with possible downstream NMDAR deactivation. The investigators will examine AV-101 NMDAR modulation by testing dose-response effects on resting state EEG, Mismatch Negativity, and P50 gating. Twelve healthy Operation Enduring Freedom (OEF) Operation Iraqi Freedom (OIF) and Operation New Dawn (OND) Veterans will be administered single dose AV-101 720 mg, 1440 mg, and placebo over 3 weeks in a randomized, double-blind, cross-over trial. Repeated measures General Linear Models will test dose-response effects. Suicide prevention is an important Veterans Affair (VA) mission. This study is a first step to testing anti-suicidal effects of AV-101 in Veterans.

Healthy

Marijn Lijffijt, PhD18 participantsStarted Sep 2018

Houston, Texas, United States

TERMINATEDPhase 3< 1 mile

COVID-19 Positive Outpatient Thrombosis Prevention in Adults Aged 40-80

NCT04498273

A multi-center adaptive randomized placebo-controlled platform trial evaluating the efficacy and safety of anti-thrombotic strategies in COVID-19 adults not requiring hospitalization at time of diagnosis

COVID-19

Frank C Sciurba657 participantsStarted Sep 2020

Los Angeles, California, United States • Palo Alto, California, United States • San Francisco, California, United States +68 more locations

Electrophysiological Biomarkers of AV-101

COVID-19 Positive Outpatient Thrombosis Prevention in Adults Aged 40-80

Find Trials by Condition in Houston

NA-831, Atazanavir and Dexamethasone Combination Therapy for the Treatment of COVID-19 Infection

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia

Non Invasive Oral Cancer Screening Among HIV Infected Individuals

Energetics and Function in Older Humans

5-Year Safety Study of Pimecrolimus Cream 1% in Infants 3 - 12 Months of Age With Mild to Moderate Atopic Dermatitis

X-82 to Treat Age-related Macular Degeneration

Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE)

Novel Cardiac Signal Processing System

Efficacy and Safety of Amantadine Hydrogen Chloride (HCl) ER Tablets in Parkinson's Disease Subjects With LID

Expanded Access Remdesivir (RDV; GS-5734™)

Ph1b Study of Oraxol in Comb. w. Ramucirumab in Patients w. Gastric, Gastro-esophageal, or Esophageal Cancers

Risk Reduction for Alzheimer's Disease

Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer

Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers

PEN-866 in Patients With Advanced Solid Malignancies

SUSTAIN-IT: Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support?

Multi-Dose Safety/Pharmacodynamic Study of SEL-212/SEL-037 in Subjects With Symptomatic Gout & Elevated Blood Uric Acid