Clinical Trials in Houston

Showing 5161-5180 of 17,885 trials

Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

NCT04113434

The overall goal of the study is to risk stratify pediatric Acute Respiratory Distress Syndrome (ARDS) patients and to identify sub-phenotypes with shared biology in order to appropriately target therapies in future trials. This is a prospective, multicenter study of 500 intubated children with ARDS, with planned blood collection within 24 hours of ARDS onset and subsequent measurement of plasma protein biomarkers and peripheral blood gene expression.

Acute Respiratory Distress Syndrome

Children's Hospital of Philadelphia500 participantsStarted Jan 2020

Little Rock, Arkansas, United States • Aurora, Colorado, United States • Miami, Florida, United States +13 more locations

COMPLETEDPhase 4< 1 mile

A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression

NCT04599855

The purpose of this study is to evaluate the efficacy of each individual dose of esketamine nasal spray, 56 milligram (mg) and 84 mg, compared with placebo nasal spray in improving depressive symptoms in participants with treatment resistant depression (TRD), as assessed by the change from baseline in the Montgomery-Asberg Depression Rating Scale (MADRS) total score from Day 1 (prerandomization) to the end of the 4 week double-blind treatment phase (Day 28).

Depressive Disorder, Treatment-Resistant

Janssen Research & Development, LLC477 participantsStarted Nov 2020

Birmingham, Alabama, United States • Huntsville, Alabama, United States • Little Rock, Arkansas, United States +51 more locations

Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression

Find Trials by Condition in Houston

Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency

A Trial of Setanaxib in Patients With Primary Biliary Cholangitis (PBC) and Liver Stiffness

Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System

Predictive Analytics and Clinical Decision Support to Improve PrEP Prescribing

Exemestane, Letrozole, or Anastrozole in Treating Postmenopausal Women Who Are Undergoing Surgery for Stage II or Stage III Breast Cancer

A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease

Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

Treatment of Persistent Atrial Fibrillation With Sphere-9 Catheter and Affera Mapping and Ablation System

HiLo: Pragmatic Trial of Higher vs Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis

Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis

A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

DALY II USA/ MB-CART2019.1 for DLBCL

Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma

Phase 2b Study of MBS2320 in Participants With Methotrexate-Refractory RA

User Acceptability Evaluation of Pseudophakic Patients Previously Implanted With the TECNIS Odyssey IOL

Comparative Study of Conventional MR Images With Synthetically Reconstructed MR Images of the Brain

A Study of JNJ-73763989 + Nucleos(t)Ide Analog in Participants Co-Infected With Hepatitis B and Hepatitis D Virus