Clinical Trials in Detroit

Showing 16661-16680 of 19,719 trials

Hypothermia During ECMO to Decrease Brain Injury

NCT01675388

Newborn infants with severe respiratory failure are treated with extracorporeal membrane oxygenation (ECMO), a modified form of cardiopulmonary bypass. These infants as at risk for brain injury as a result of hypoxia and blood flow changes in the brain prior to and during ECMO. The investigators propose a clinical trial of a novel treatment (cooling during ECMO) and novel diagnostic tool (advanced MRI techniques) that will lead to improved outcomes, early diagnosis and intervention for brain injury, decreased cost and duration of clinical trials, decrease in the burden of chronic neurologic disease and disability in society, thus improving the health and quality of life of these infants as they progress through childhood into adulthood.

Neonatal Respiratory Failure

Sood, Beena G., MD, MSStarted Aug 2012

Detroit, Michigan, United States

COMPLETEDPhase 1/2< 1 mile

Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma

NCT00024570

IL13-PE38QQR is an oncology drug product consisting of IL13 (interleukin-13) and PE38QQR (a bacteria toxin). IL3-PE38QQR is a protein that exhibits cell killing activity against a variety of IL13 receptor-positive tumor cell lines indicating that it may show a therapeutic benefit. In reciprocal competition experiments, the interaction between IL13-PE38QQR and the IL13 receptors was shown to be highly specific for human glioma cells. IL13-PE38QQR will be infused in two courses of 96 hours each, eight weeks apart, directly into the malignant brain tumors of patients to determine the dose of drug these patients can tolerate. After that, the selected dose will be studied to give an estimate of the response rate, response duration, time to response, and survival after infusing that dose of IL13-PE38QQR into the recurrent malignant glioma.

Malignant GliomaGlioblastoma MultiformeAnaplastic Astrocytoma+1 more

INSYS Therapeutics Inc60 participantsStarted Nov 2000

Birmingham, Alabama, United States • Tampa, Florida, United States • Atlanta, Georgia, United States +5 more locations

Hypothermia During ECMO to Decrease Brain Injury

Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma

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Validation of a Novel Diagnostic, Prognostic Assay for Bacterial Vaginosis

Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC)

Study to Assess the Clinical Efficacy and Safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) in Patients With Branch Retinal Vein Occlusion (BRVO)

Dissemination of Tobacco Tactics for Hospitalized Smokers

Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Registry of AngioJet Use in the Peripheral Vascular System

Efficacy Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Platinum-Refractory Head and Neck Cancers

Study of a Single Dose of Menactra® Vaccine 4-6 Years After Prior Menactra Vaccine

Renal Denervation in Patients With Refractory Hypertension

A Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting

Efficacy and Safety of Gadobutrol 1.0 Molar (Gadovist) for Breast Magnetic Resonance Imaging (MRI)

Phase I/II Trial of Intracerebral IL13-PE38QQR Infusions in Pediatric Patients With Recurrent Malignant Glioma

Encapsulated Calcium Absorption in Pregnancy

Treatment Trial for Psychogenic Nonepileptic Seizures

Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma

Phase 1b/2 Study of Retaspimycin HCl (IPI-504) in Combination With Everolimus in KRAS Mutant Non-small Cell Lung Cancer

An Exploratory Study of FP01 Lozenges in Subjects With Chronic Refractory Cough

DPBRN Reasons for Placing the First Restoration on Permanent Tooth Surfaces