Clinical Trials in Detroit

Showing 1481-1500 of 16,931 trials

Safety and Efficacy of a Drug Eluting Slim Modiolar Electrode Array

NCT06598059

This clinical study will test a new type of cochlear implant known as CI632D. This experimental cochlear implant has been designed to slowly release a drug called dexamethasone. Dexamethasone works to ease inflammation and reduce tissue injury, which is common after any type of surgery. The goal is to learn if the dexamethasone in the CI632D implant lessens these reactions inside the ear following surgery and if this makes the implant work as well, or even better, in improving hearing than what would be expected with a standard cochlear implant. The study will be conducted in adults with sensorineural hearing loss, a type of hearing loss caused by damage to the inner ear or auditory nerve (the nerve that carries sound signals from the ear to the brain). The study participants will receive the CI632D experimental implant and will complete tests to see how well they are hearing and how well the implant is working.

Hearing Loss

Cochlear56 participantsStarted Jan 2025

Los Angeles, California, United States • Englewood, Colorado, United States • Iowa City, Iowa, United States +8 more locations

RECRUITINGPhase 1/2< 1 mile

Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

NCT06014658

This is a first-in-human (FIH), open label Phase 1/1b / Phase 2 study in patients with advanced metastatic solid tumors refractory to standard treatment. Phase 1 will identify potential optimal biologically relevant doses (OBRD) and the maximum tolerated dose (MTD) of MBRC-101 at one 1 or more dosing regimens. Phase 1b will evaluate the safety and preliminary clinical activity of MBRC-101 at potential OBRDs. Phase 1 and Phase 1b will both characterize single and multiple-dose PK profiles and evaluate incidence and persistence of anti-MBRC-101 Ab. Phase 2 will evaluate the efficacy of MBRC-101 at the RP2D from Phase1b.

Cancer

MBrace Therapeutics130 participantsStarted Nov 2023

San Francisco, California, United States • Aurora, Colorado, United States • Atlanta, Georgia, United States +14 more locations

Safety and Efficacy of a Drug Eluting Slim Modiolar Electrode Array

Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

Find Trials by Condition in Detroit

Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body

A Dose Range-Finding Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD8630 in Adults With Uncontrolled Asthma at Risk of Exacerbations

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

Facilitating Psychological Closure and Emotional Change Through Mindfulness Meditation

Comparing Two Methods to Follow Patients With Pancreatic Cysts

Water Vapor Ablation for Localized Intermediate Risk Prostate Cancer

Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of SION-719 When Added to Trikafta

A Prospective, Multicenter, Study of APF530 (Granisetron) SC for Prevention of CINV in Patients Receiving HEC

QTX3544 in Patients With Advanced Solid Tumors With KRAS G12V Mutations

A Study of LY4175408 in Participants With Advanced Cancer

A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly

Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

Dose-Escalation Study of Cenobamate (YKP3089) in Pediatric Subjects With Partial-Onset Seizures

Evaluating the Communication Between Patients and Providers in Cancer Clinics

ADVENT Post Approval Study

A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease (NPC)

Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE)

Neurostimulation for Treatment of Chronic Upper Limb Pain After Brachial Plexus Injury