Clinical Trials in Detroit

Showing 11361-11380 of 19,719 trials

Safety and Efficacy of Melflufen and Dexamethasone in Relapsed and/or Relapsed-Refractory Multiple Myeloma Patients

NCT01897714

The study will explore escalating doses of melflufen in combination with dexamethasone in small groups of patients to find the maximum tolerated dose of melflufen. That dose will then be used to determine the efficacy and safety profile of melflufen in combination with dexamethasone in a larger group of patients.

Relapsed and/or Relapsed-refractory Multiple Myeloma

Oncopeptides AB75 participantsStarted Jul 2013

Boston, Massachusetts, United States • Detroit, Michigan, United States • Chapel Hill, North Carolina, United States +4 more locations

TERMINATEDPhase 213 miles

Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-Related Macular Degeneration (AMD)

NCT02418754

The primary objective of the study was to explore the effect of REGN2176-3 on the Early Treatment Diabetic Retinopathy Scale (ETDRS) best-corrected visual acuity (BCVA) in participants with neovascular age-related macular degeneration (AMD), compared to intravitreal aflibercept injection (IAI) monotherapy. The secondary objectives of the study were the following: * To explore the effect of 2 dose levels of IVT REGN2176-3 on anatomical changes of CNV in participants with nAMD compared to IAI monotherapy (at week 12) * To evaluate if short-term treatment with REGN2176-3 followed by IAI monotherapy offered the same or additional benefit compared to continuous treatment with REGN2176-3. Also to determine if there was benefit in initiating IAI treatment prior to REGN2176-3 compared to continuous treatment with IAI. * To assess the safety and tolerability of IVT REGN2176-3 in participants with nAMD

Neovascular Age-Related Macular Degeneration

Regeneron Pharmaceuticals505 participantsStarted May 2015

Phoenix, Arizona, United States • Tucson, Arizona, United States • Arcadia, California, United States +81 more locations

Safety and Efficacy of Melflufen and Dexamethasone in Relapsed and/or Relapsed-Refractory Multiple Myeloma Patients

Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-Related Macular Degeneration (AMD)

Find Trials by Condition in Detroit

The Impact of Heartfulness Program on Loneliness in High School Students in the US

Clinical Investigation of New CI Delivery Models in an Adult Nucleus CI Population

Influence of Mucosa Tissue Thickness on Marginal Bone Loss of Implants With Smooth Collars

Safety and Efficacy of OT-82 in Participants With Relapsed or Refractory Lymphoma

A Safety and Efficacy Trial of Inhaled Mannitol in Adult Cystic Fibrosis Subjects

Randomized Trial of COBRA PzF Stenting to Reduce Duration of Triple Therapy

Study to Assess Safety and Efficacy of Filgotinib, Lanraplenib and Tirabrutinib in Adults With Active Sjogren's Syndrome

A Study of A-101 Topical Solution for the Treatment of Common Warts

Telehealth Powerful Tools for Caregivers Effectiveness Study

Study to Evaluate the Safety and Effectiveness of the CODMAN ENTERPRISE® Vascular Reconstruction Device

A Study of Pertuzumab in Combination With Trastuzumab Plus an Aromatase Inhibitor in Participants With Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive and Hormone Receptor-Positive Advanced Breast Cancer

Danirixin Dose Ranging Study in Participants With Chronic Obstructive Pulmonary Disease (COPD)

The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias

Topical Rapamycin to Erase Angiofibromas in TSC

A Randomized Phase 2 Study of Ixabepilone Plus Carboplatin and Paclitaxel Plus Carboplatin in Advanced Nonsmall-Cell Lung Cancer

Sebacia Postmarket Study of Real-World Use

Cholinesterase Inhibitor Discontinuation

Exploratory Study of Relationships Between Malodor and Urine Metabolomics