Clinical Trials in Denver

Showing 10581-10600 of 18,161 trials

A Dose Escalation and Cohort-Expansion Study of Oral eFT508 in Subjects With Advanced Solid Tumors

NCT02605083

This clinical trial is a Phase 1-2, open-label, sequential-group, dose-escalation and cohort-expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of daily oral administration of eFT508.

Cancer

Effector Therapeutics66 participantsStarted Dec 2015

Denver, Colorado, United States • Sarasota, Florida, United States • Nashville, Tennessee, United States +1 more locations

COMPLETEDPhase 2< 1 mile

A Study of Pertuzumab in Combination With Trastuzumab Plus an Aromatase Inhibitor in Participants With Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive and Hormone Receptor-Positive Advanced Breast Cancer

NCT01491737

This randomized, open-label, two-arm, multi-center, Phase II study will evaluate the efficacy and safety of pertuzumab in combination with trastuzumab plus an aromatase inhibitor (AI) in first-line participants with HER2-positive and hormone receptor-positive advanced breast cancer. Participants will be randomized to one of two treatment arms; Arm A (pertuzumab in combination with trastuzumab plus an AI) or Arm B (trastuzumab plus an AI). Participants may also receive induction chemotherapy (a taxane, either docetaxel or paclitaxel) at the investigator's discretion in combination with the assigned treatment arm. The anticipated time on study treatment is until disease progression, unacceptable toxicity, withdrawal of consent, or death whichever occurs first.

Breast Cancer

Hoffmann-La Roche258 participantsStarted Feb 2012

Birmingham, Alabama, United States • Chandler, Arizona, United States • Hot Springs, Arkansas, United States +79 more locations

A Dose Escalation and Cohort-Expansion Study of Oral eFT508 in Subjects With Advanced Solid Tumors

A Study of Pertuzumab in Combination With Trastuzumab Plus an Aromatase Inhibitor in Participants With Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive and Hormone Receptor-Positive Advanced Breast Cancer

Find Trials by Condition in Denver

A Study of A-101 Topical Solution for the Treatment of Common Warts

Clinical Investigation of New CI Delivery Models in an Adult Nucleus CI Population

Surgical Telemedicine in the COVID-19 Pandemic Era

Pilot Study of Treatment for Subclinical AMR (Antibody-mediated Rejection) in Kidney Transplant Recipients

Biomarkers of Insufficient Sleep and Sleepiness

A Multi-Center Controlled Screening Trial of Safety and Efficacy of Lithium Carbonate in Subjects With Amyotrophic Lateral Sclerosis (ALS)

Telehealth Powerful Tools for Caregivers Effectiveness Study

Danirixin Dose Ranging Study in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Megestrol in Treating Patients With Endometrial Neoplasia or Endometrial Hyperplasia

A Safety and Efficacy Trial of Inhaled Mannitol in Adult Cystic Fibrosis Subjects

An Evidence Based Delivery Model of Care for Newly Implanted Adult CI Recipients

Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis

Vectors Post Market: A Study to Assess Pain Relief Using Spinal Cord Stimulation

A Study to Assess Safety and Efficacy of KarXT in Adult Patients With Schizophrenia

A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral Tomivosertib (eFT-508) in Subjects With Hematological Malignancies

Topical Rapamycin to Erase Angiofibromas in TSC

Sebacia Postmarket Study of Real-World Use

A Randomized Phase 2 Study of Ixabepilone Plus Carboplatin and Paclitaxel Plus Carboplatin in Advanced Nonsmall-Cell Lung Cancer