Clinical Trials in Denver

Showing 5081-5100 of 18,161 trials

Study of AGEN1571 in Participants With Advanced Solid Tumors

NCT05377528

This is an open-label, Phase 1, 2-part trial to determine recommended phase 2 doses (RP2Ds) and evaluate the safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of AGEN1571 both as a monotherapy and in combination with balstilimab (PD-1 inhibitor) and/or botensilimab (2-agent combination or 3-agent combination) in participants diagnosed with advanced solid tumors. Part 1 will be the dose escalation phase to determine the RP2D of AGEN1571 monotherapy or AGEN1571 in combination with balstilimab and/or botensilimab. Part 2 will be the dose expansion phase for specific disease indications. Participants will receive study treatment for up to 2 years, or until any disease progression, unacceptable toxicity, or participant wishes to withdraw consent for any reason.

Advanced Solid Tumor

Agenus Inc.22 participantsStarted Jul 2022

Los Angeles, California, United States • Denver, Colorado, United States • Sarasota, Florida, United States +3 more locations

RECRUITING< 1 mile

Chronic Pain in Rheumatoid Arthritis

NCT05038553

The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been shown to be involved in chronic pain.

Arthritis, RheumatoidPain

Northwestern University125 participantsStarted Oct 2021

Denver, Colorado, United States • Chicago, Illinois, United States • Baltimore, Maryland, United States +2 more locations

Study of AGEN1571 in Participants With Advanced Solid Tumors

Chronic Pain in Rheumatoid Arthritis

Find Trials by Condition in Denver

A Study of Ustekinumab in Participants With Active Systemic Lupus Erythematosus

A Study of Suboptimally Controlled Participants Previously Taking Injectable DMDs for RMS (CLICK-MS)

Thermogenenic Responses to Fasting and Overfeeding in Women

IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Progressive Multiple Sclerosis

Zibotentan and Dapagliflozin in Patients With Type 2 Diabetes and Elevated Albuminuria

An Investigation to Validate Speech Perception Assessment for Adult Cochlear Recipients Using a Mobile Research App

A Study to Evaluate the Safety and Efficacy of Ustekinumab Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea

ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES

A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome

A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(Alpha) Refractory Participants With Active Radiographic Axial Spondyloarthritis

Safety, Tolerability and Efficacy of ACZ885 on Leg Artery Structure in Patients With Peripheral Artery Disease

Derm-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone

Expanded Access for Cancer Treatment With Balstilimab (AGEN2034) and Zalifrelimab (AGEN1884)

Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children

APX005M and Doxorubicin in Advanced Sarcoma

A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression

Study of Dabrafenib+Trametinib in the Adjuvant Treatment of Stage III BRAF V600+ Melanoma After Complete Resection to Evaluate the Impact on Pyrexia Related Outcomes