Clinical Trials in Dallas

Showing 2201-2220 of 15,003 trials

Determining the Association of TTR Stabilizing Therapy With Circulating TTR Amyloid Aggregates Over Time in Patients With ATTR-CM: Longitudinal Biomarker Study

NCT07196839

The objective of this study is to determine the association of clinically prescribed, on-label, TTR stabilizing therapy (e.g. tafamidis or acoramidis) with levels of circulating transthyretin amyloid aggregates (TAAs, a surrogate for amyloid disease activity) measured serially over time in patients with transthyretin cardiac amyloidosis (ATTR-CA). To accomplish this objective, the hypothesis that TTR stabilizing therapy will be associated lower circulating TAAs over time will be tested. Completion of this study will advance the understanding of the influence of ATTR-CA treatments on circulating evidence of amyloidosis and justify the role of blood testing to monitor treatment response in patients with ATTR-CA.

Transthyretin (TTR) Amyloid Cardiomyopathy

University of Texas Southwestern Medical Center50 participantsStarted Dec 2025

Dallas, Texas, United States

RECRUITINGPhase 1/2< 1 mile

A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

NCT06399757

This is an open-label, Phase 1/2 study to determine the safety, tolerability, and efficacy of APL-5125 for the treatment of selected locally advanced or metastatic solid tumors with particular focus on Colorectal carcinoma (CRC).

Colorectal CancerCholangiocarcinomaAppendiceal Adenocarcinoma+6 more

Apollo Therapeutics Ltd100 participantsStarted Jun 2024

Duarte, California, United States • Irvine, California, United States • Sarasota, Florida, United States +6 more locations

Determining the Association of TTR Stabilizing Therapy With Circulating TTR Amyloid Aggregates Over Time in Patients With ATTR-CM: Longitudinal Biomarker Study

A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

Find Trials by Condition in Dallas

Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)

Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy

A Study of CT-388 in Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus

Safety and Tolerability of IPH4502 in Patients With Advanced Solid Tumors

Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS

Poly-4-Hydroxybutyrate Scaffold in Rhytidectomy

Patch-free Occlusion Therapy

Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy

A Study to Evaluate AI-09 In Participants With Glabellar Lines

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies

Conservative Surgery in Treating Patients With Low-Risk Stage IA2 or IB1 Cervical Cancer

RewinD-LB - Clinical Study of Neflamapimod in Patients With Dementia With Lewy Bodies

A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)

CD40-L Blockade for Prevention of Acute Graft-Versus-Host Disease

Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.

First-in-Human, Phase I, Open-label, Multicenter, Dose Escalation Clinical Study