Clinical Trials in Cleveland

Showing 3121-3140 of 19,775 trials

Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery

NCT05334485

A double blind, placebo controlled, randomized control trial studying the safety and efficacy of pyridostigmine as a rescue therapy for postoperative ileus. Patients who undergo elective colorectal resection with or without creation of an ostomy, and subsequently develop postoperative ileus will be eligible for enrollment. Patients will be randomized to receive either pyridostigmine or placebo in addition to the current elements of standard of care. Patients will also complete the pyridostigmine bromide side effects scale (PBSES) upon enrollment and following each administration of either intervention or placebo to monitor treatment safety and evaluate for the development of side effects.

Postoperative Ileus

Stefan Holubar MD MS FACS, FASCRS50 participantsStarted Sep 2024

Cleveland, Ohio, United States

COMPLETEDPhase 3< 1 mile

Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)

NCT04458051

Primary Objective: To determine the efficacy of SAR442168 compared to placebo in delaying disability progression in primary progressive multiple sclerosis (PPMS) Secondary Objectives: To evaluate efficacy of SAR442168 compared to placebo on clinical endpoints, magnetic resonance imaging (MRI) lesions, cognitive performance, physical function, and quality of life To evaluate safety and tolerability of SAR442168 To evaluate population pharmacokinetics (PK) of SAR442168 in PPMS and its relationship to efficacy and safety To evaluate pharmacodynamics of SAR442168

Primary Progressive Multiple Sclerosis

Sanofi767 participantsStarted Aug 2020

La Jolla, California, United States • Los Alamitos, California, United States • Los Angeles, California, United States +274 more locations

Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery

Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)

Find Trials by Condition in Cleveland

Viability Assessment Using FMN Measured in Perfusate and Bile During Normothermic Machine Perfusion

Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis

[18F]PI-2620 Phase 3 Histopathological Study

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus

A Study of CT-388 in Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus

First-in-Human, Phase I, Open-label, Multicenter, Dose Escalation Clinical Study

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition

Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)

International Registry of Intra-arterial and Endosaccular Flow Diverters (IRF)

A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)

Safety and Tolerability of IPH4502 in Patients With Advanced Solid Tumors

Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet)

Acupuncture for Chronic Low Back Pain in Older Adults

AB154 Combined With AB122 for Recurrent Glioblastoma

DAREONᵀᴹ-8: A Study to Test How Well Different Doses of BI 764532 in Addition to Standard of Care Are Tolerated by People With Advanced Small Cell Lung Cancer

A Phase 1b Study of Budoprutug in Systemic Lupus Erythematosus (SLE)

Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.