Clinical Trials in Cleveland

Showing 2741-2760 of 16,969 trials

Long-term Follow-up of a Cochlear Implant With Dexamethasone Eluting Electrode Array

NCT06936449

A long-term follow-up of Cochlear's cochlear implant electrode array which passively elutes dexamethasone for a defined period of time to help reduce inflammatory responses.

Sensorineural Hearing LossBilateral Hearing Loss

Cochlear19 participantsStarted May 2025

Englewood, Colorado, United States • Iowa City, Iowa, United States • Cleveland, Ohio, United States

COMPLETEDPhase 2< 1 mile

EG-501 for Cognitive Impairment in Neuropsychiatric SLE (NPSLE): Efficacy and Safety Study

NCT07281105

Neuropsychiatric systemic lupus erythematosus with cognitive impairment (NPSLE-CI) is a serious, disabling, and potentially life-threatening manifestation of SLE, affecting up to 80% of patients with cognitive impairments ("brain fog"), leading to substantial disability, approximately 2 times higher unemployment risk, reduced health-related quality of life (HRQoL), and mortality 2-14 times higher than the general population (standardized mortality ratio, SMR). No approved therapies exist for NPSLE cognitive dysfunction, representing a high-priority unmet need for this FDA-recognized serious condition with major functional and psychosocial burden. The objective of this study is to evaluate the safety, tolerability and efficacy of EG-501 in a precise patient subset with NPSLE. Participants will complete a full 14-week clinical trial, receiving either EG-501 or a placebo.

Neuropsychiatric Systemic Lupus ErythematosusSystemic Lupus Erythematosus (SLE)Cognitive Impairment

Evergreen Therapeutics, Inc.131 participantsStarted Aug 2018

Cleveland, Ohio, United States • Nashville, Tennessee, United States • Houston, Texas, United States

Long-term Follow-up of a Cochlear Implant With Dexamethasone Eluting Electrode Array

EG-501 for Cognitive Impairment in Neuropsychiatric SLE (NPSLE): Efficacy and Safety Study

Find Trials by Condition in Cleveland

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries

Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan

Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)

Open Label, Dose-finding, Pharmacokinetics, Safety and Tolerability Study of Oritavancin in Pediatric Participants With Suspected or Confirmed Bacterial Infections

A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age

A Study to Evaluate MORF-057 in Adults With Moderately to Severely Active UC

Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer.

A Study of HBS-201 (Pitolisant Delayed-release)

A Phase 1/2 Study of D3S-002 as Monotherapy or Combination Therapy in Adult Subjects With Advanced Solid Tumors With MAPK Pathway Mutations

ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients

Study of Oral Food Challenge Biomarkers (SAFER)

A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)

Safely Optimizing Body Weight With TCMCB07 in Patients With Newly Diagnosed Metastatic Colorectal Cancer Undergoing Chemotherapy

A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis

A Research Study to Compare Two Semaglutide Medicines in People With Type 2 Diabetes

Ulixertinib in People With Histiocytic Neoplasms

Acceptability and Safety of MR-C-014 in Persons With Neuromyelitis Optica Spectrum Disorder