Clinical Trials in Chicago

Showing 8061-8080 of 20,493 trials

A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-Thalassemia

NCT03342404

This is a Phase 2, double-blind, randomized, placebo-controlled, multicenter study to determine the efficacy and safety of luspatercept (ACE-536) versus placebo in adults with non-transfusion dependent beta (β)-thalassemia. The study is divided into the Screening Period, Double-blind Treatment Period (DBTP), Open-label Phase (OLP), and Post-Treatment Follow-up Period (PTFP). It is planned to randomize approximately 150 subjects at a 2:1 ratio of luspatercept versus placebo.

Thalassemia

Celgene145 participantsStarted Feb 2018

Los Angeles, California, United States • Los Angeles, California, United States • Oakland, California, United States +13 more locations

COMPLETEDPhase 22.2 miles

Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas

NCT03783936

The initial intent of the study was to be a multi-center single-arm open-label Simon's two-stage Phase II clinical trial of first-line mFOLFOX6 + trastuzumab + avelumab in metastatic HER2-amplified gastric and esophageal adenocarcinomas. Accrual will halt after completion of Stage I (enrollment of 18 patients). This decision is not due to safety issues. Subjects currently on treatment will continue until criteria as defined in the protocol is met.

Gastric AdenocarcinomaEsophageal AdenocarcinomaMetastasis+1 more

Ashwin Somasundaram18 participantsStarted Jan 2019

Duarte, California, United States • Atlanta, Georgia, United States • Chicago, Illinois, United States +4 more locations

A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-Thalassemia

Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas

Find Trials by Condition in Chicago

Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease

Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III)

Adjuvant Sequential & Concurrent CarboTaxol + Radiotherapy for High Risk Endometrial Cancer

Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy

Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes (CLVer): Extension Study

Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study

Second-line Treatment of HIV-1 With Ritonavir Boosted Atazanavir or Darunavir With an Optimized NRTI Backbone

A Study to Assess the Safety, Efficacy and Tolerability of AZD8233 Treatment in Participants With Hyperlipidaemia

A Study of [225Ac]-FPI-1966 in Participants With Advanced Solid Tumours

AkLief Evaluation in Acne-induced Post-Inflammatory Hyperpigmentation

A Clinical Study Evaluating Nivolumab-containing Treatments in Patients With Advanced Non-small Cell Lung Cancer After Failing Previous PD-1/(L)1 Therapy and Chemotherapy

Opioid Use Disorder in the Emergency Department: CTN 0069

Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma

Study of the CD40 Agonistic Monoclonal Antibody APX005M

A Study of RVT-1401 in Myasthenia Gravis (MG) Patients

Intranasal Oxytocin for Frontotemporal Dementia

Reveal LINQ Respiration Clinical Study

Survival Prolongation by Rationale Innovative Genomics