Clinical Trials in Chicago

Showing 3901-3920 of 20,493 trials

Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

NCT02199665

This phase I trial studies the side effects and best dose of selinexor and carfilzomib when given together with dexamethasone in treating patients with multiple myeloma that has returned or does not respond to treatment. Drugs used in chemotherapy, such as selinexor and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving selinexor, carfilzomib, and dexamethasone may be a better treatment for multiple myeloma.

Refractory Multiple Myeloma

University of Chicago52 participantsStarted Jun 2014

Scottsdale, Arizona, United States • Chicago, Illinois, United States • Ann Arbor, Michigan, United States +2 more locations

Not Yet RecruitingPhase 1/22.2 miles

Improving Walking After Spinal Cord Injury

NCT07223710

Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to SCI. Although studies have shown that locomotor training improves locomotor function in people with chronic SCI, the benefits remain limited. Our overall hypothesis is that we can engage additional descending motor pathways, such as the reticulospinal tract (RST), to improve locomotor function in humans with chronic incomplete SCI. In this study we propose to test the effects of a novel intervention that uses repeated paired loud auditory and electrical stimulation of muscle afferents combined with locomotor training on walking speed and voluntary muscle strength.

Spinal Cord Injury

Shirley Ryan AbilityLab20 participantsStarted Nov 2025

Chicago, Illinois, United States

Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

Improving Walking After Spinal Cord Injury

Find Trials by Condition in Chicago

Clinical Trial Evaluating ITI-007 (Lumateperone) as a Monotherapy for the Treatment of Bipolar Depression

The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD)

Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)

Photographic Evidence on Total Knee Arthroplasty Outcomes

Post-Market Study to Assess iTind Safety in Comparison to UroLift

A Study to Describe the Characteristics, Health Care Interventions and Outcomes of Patients With Major Bleedings in the Presence of Factor Xa Inhibitor Treatment

Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC).

Neuspera's Implantable Sacral Nerve Stimulation System in Patients With Symptoms of Urinary Urgency Incontinence (UUI)

Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

Open-label Extension of the HOPE-2 Trial

Combining a Smartphone App With Medications to Manage Heavy Drinking

Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1

ZILRETTA in Subjects With Shoulder Osteoarthritis

To Evaluate Safety and Tolerability of the Fixed- Dose Combination of Obeticholic Acid and Bezafibrate

A Modular Phase 1/2 Study With CT7439 in Participants With Solid Malignancies

Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial

SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST