Clinical Trials in Chicago

Showing 3181-3200 of 17,609 trials

Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

NCT02199665

This phase I trial studies the side effects and best dose of selinexor and carfilzomib when given together with dexamethasone in treating patients with multiple myeloma that has returned or does not respond to treatment. Drugs used in chemotherapy, such as selinexor and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving selinexor, carfilzomib, and dexamethasone may be a better treatment for multiple myeloma.

Refractory Multiple Myeloma

University of Chicago52 participantsStarted Jun 2014

Scottsdale, Arizona, United States • Chicago, Illinois, United States • Ann Arbor, Michigan, United States +2 more locations

RECRUITINGPhase 1/22.2 miles

The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

NCT04329728

This is an open-label, Phase 1/2 study designed to characterize the safety, tolerability, Pharmacokinetics(PK), and preliminary antitumor activity of AVM0703 administered as a single intravenous (IV) infusion to patients with lymphoid malignancies.

Lymphoid Malignancies

AVM Biotechnology Inc144 participantsStarted Nov 2020

Duarte, California, United States • Los Angeles, California, United States • Los Angeles, California, United States +8 more locations

Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

Find Trials by Condition in Chicago

Clinical Trial Evaluating ITI-007 (Lumateperone) as a Monotherapy for the Treatment of Bipolar Depression

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer

Home-based Optimization of Mechanical Ventilation in Children

Photographic Evidence on Total Knee Arthroplasty Outcomes

A Study to Describe the Characteristics, Health Care Interventions and Outcomes of Patients With Major Bleedings in the Presence of Factor Xa Inhibitor Treatment

Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC).

Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

Open-label Extension of the HOPE-2 Trial

Combining a Smartphone App With Medications to Manage Heavy Drinking

Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1

ZILRETTA in Subjects With Shoulder Osteoarthritis

A Phase 2a Proof-of-Concept Trial of Bempikibart (ADX-914) for the Treatment of Severe Alopecia Areata (SIGNAL-AA)

Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab (Phase 1a) and Pegylated Liposomal Doxorubicin (Phase 1b) as Treatment for Ovarian Cancer.

To Evaluate Safety and Tolerability of the Fixed- Dose Combination of Obeticholic Acid and Bezafibrate

Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Adolescent Stargardt Disease

A Modular Phase 1/2 Study With CT7439 in Participants With Solid Malignancies

SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST