Clinical Trials in Boston

Showing 1681-1700 of 15,299 trials

Developing Resiliency and Exercise Using AI-based Messaging

NCT07225283

This is a randomized, controlled pilot trial to examine the feasibility, acceptability, and preliminary efficacy of the DREAM program, an 8-week message-based intervention to promote physical activity and well-being in adults with type 2 diabetes.

Diabetes Mellitus Type 2

Massachusetts General Hospital20 participantsStarted Apr 2026

Boston, Massachusetts, United States

COMPLETEDPhase 1< 1 mile

Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants With Myotonic Dystrophy Type 1

NCT06204809

The primary purpose of the study is to evaluate the safety and tolerability of single intravenous (IV) doses of PGN-EDODM1 administered to participants with Myotonic Dystrophy Type 1 (DM1). The study consists of 2 periods: A Screening Period (up to 30 days) and a Treatment and Observation Period (16 weeks).

Myotonic Dystrophy 1

PepGen Inc24 participantsStarted Dec 2023

Irvine, California, United States • Palo Alto, California, United States • Atlanta, Georgia, United States +9 more locations

Active Not RecruitingPhase 2< 1 mile

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

NCT05774665

The goal of this clinical trial is to determine the impact of omega-3 fatty acids on the production of anti-inflammatory effects and clinical improvement in people with depression who have not responded well to standard antidepressant treatment. The main questions it seeks to answer are: 1. Do omega-3 fatty acids added to ineffective antidepressant treatment increase production of compounds that reduce inflammation? 2. Is the increase in these anti-inflammatory compounds associated with a stronger antidepressant effect? Participants taking antidepressants that have not worked completely will be assigned at random for a 12-week period to one of the following: 1. an omega-3 preparation 2. an inactive placebo During the course of the study, blood tests will be obtained for compounds associated with inflammation, and questionnaires to measure clinical improvement in depressive symptoms will be administered.

Treatment Resistant DepressionInflammationOverweight

Massachusetts General Hospital80 participantsStarted Jan 2025

Atlanta, Georgia, United States • Boston, Massachusetts, United States • Salt Lake City, Utah, United States

Developing Resiliency and Exercise Using AI-based Messaging

Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants With Myotonic Dystrophy Type 1

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

Find Trials by Condition in Boston

Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors

Eliminating Monitor Overuse Trial (EMO Trial)

Study to Assess Safety, Efficacy and Persistence of ACE1831, in Subjects With IgG4-Related Disease

A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy

Supporting Our Caregivers In ADRD Learning (SOCIAL)

Study of Bitopertin in Participants With EPP or XLP (APOLLO)

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Long-term Safety and Efficacy of Leniolisib in PIDs With Immune Dysregulation

Acceptance and Commitment Therapy to Improve Social Support for Veterans With PTSD

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

A Study to Investigate the Effect on Lung Function of BDA Formulated With a Next Generation Propellant Compared With an Approved Asthma Treatment (BDA With HFA Propellant) in Participants With Asthma

Switching to the IL-23 Inhibitor Guselkumab for People With Active IBD Who Previously Used Ustekinumab (SHIFT-IBD)

A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)

A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy

Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment