Clinical Trials in Boston

Showing 13181-13200 of 17,836 trials

Novel Pathways to Manage Inflammation and Atherosclerosis in Dialysis Patients: Role of Nicotinic Acid

NCT01159054

Patients with kidney failure on hemodialysis have an extremely high rate of cardiovascular disease including atherosclerotic cardiovascular disease. This, at least in part, is due to the chronic inflammatory status usually seen in these patients. Here we try to see if treatment with extended release nicotinic acid (Niaspan) can reduce their overall inflammatory burden (in general) and the atherosclerotic plaque inflammation (in particular).

DialysisCardiovascular DiseaseAtherosclerosis+1 more

Brigham and Women's Hospital22 participantsStarted Jul 2010

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Somerville, Massachusetts, United States

COMPLETEDPhase 1/2< 1 mile

Acute and Residual Effects of Caffeinated Beer

NCT00515294

The aim of this study is to develop information about the acute and residual effects of a new product being targeted to young adults. Using a double placebo-controlled 2 X 2 factorial model study design, we will compare the acute and residual effects on driving impairment of caffeinated alcohol, non-caffeinated alcohol, caffeinated placebo, and non-caffeinated placebo. Under the alcohol conditions, participants will receive sufficient alcoholic beverage to attain a blood alcohol concentration (BAC) of .12 g%. Participants will be 144 undergraduate and graduate students, and recent college graduates.

Neurobehavioral ManifestationsDrug Related Sleep DisturbanceAlcohol Intoxication

Boston University154 participantsStarted Oct 2006

Boston, Massachusetts, United States

Novel Pathways to Manage Inflammation and Atherosclerosis in Dialysis Patients: Role of Nicotinic Acid

Acute and Residual Effects of Caffeinated Beer

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Cetuximab + / - Carboplatin for Estrogen Receptor-Negative, Progesterone Receptor-Negative Metastatic Breast Cancer

Study of Voreloxin (Vosaroxin) in Older Patients With Untreated Acute Myeloid Leukemia

Collection of Patient-Reported Symptoms and Performance Status Via the Internet

S0800, Nab-Paclitaxel, Doxorubicin, Cyclophosphamide, and Pegfilgrastim With or Without Bevacizumab in Treating Women With Inflammatory or Locally Advanced Breast Cancer

Ph 1B B-701 in Combination With Pembrolizumab in Metastatic Transitional Cell Carcinoma of the Urothelial Tract

Intraoperative Fentanyl Dose on Respiratory Complications

To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN)

Telemedicine Intervention to Improve Physical Function

Investigational Study of Oral Fish Oil in Treating Parenteral Nutrition Associated Liver Disease

Treatment of Rett Syndrome With rhIGF-1 (Mecasermin [rDNA]Injection)

Vaccination With Lethally Irradiated Glioma Cells Mixed With GM-K562 Cells in Patients Undergoing Craniotomy For Recurrent Tumor

A Study of MM-111 and Paclitaxel With Trastuzumab in Patients HER2 Positive Carcinomas of the Distal Esophagus, Gastroesophageal (GE) Junction and Stomach

Reducing Problematic Substance Use in Youth With Chronic Medical Conditions

Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development

Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer

Evaluation of Sarilumab (SAR153191/REGN88) on Top of Methotrexate in Rheumatoid Arthritis Patients

BioFiber Scaffold Post-Market Observational Study

Safety Study of the Ventricular Partitioning Device (VPD) Implant System in Heart Failure Patients