Clinical Trials in Boston

Showing 11741-11760 of 17,836 trials

Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting.

NCT00351390

Levels of amino-terminal pro-brain natriuretic peptide (NT-proBNP) a hormone released from the heart in patients with heart failure (HF) are strongly prognostic of adverse events, such as hospitalization or death from HF. Therapies that are beneficial for HF (such as beta blockers or angiotensin converting enzyme inhibitors) tend to lower levels of NT-proBNP in parallel with improvements in outcomes of patients so treated. Importantly, Nt-proBNP levels may identify a patient at high risk for adverse outcome from their HF, even in periods of apparent stability. It remains unclear, however, whether treating patients based on their NT-proBNP concentrations would be associated with better outcomes compared to standard HF therapy without measurement of NT-proBNP values. The goal of the PROTECT study is to evaluate whether treatment of patients with advanced and recently destabilized HF would benefit from NT-proBNP guided HF treatment, compared to standard HF therapy without such 'hormone guided' treatment.

Congestive Heart Failure

Massachusetts General Hospital152 participantsStarted Sep 2005

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

Inappropriate Shock Reduction wIth PARAD+ Rhythm DiScrimination

NCT01410552

ISIS- ICD study has been designed to evaluate the impact of PARAD+ algorithm on inappropriate shocks, in a general population implanted for primary or secondary prevention with a dual or tri chamber device at one year follow-up

Tachycardia

MicroPort CRM1,013 participantsStarted Oct 2011

Mesa, Arizona, United States • Mesa, Arizona, United States • Peoria, Arizona, United States +77 more locations

Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting.

Inappropriate Shock Reduction wIth PARAD+ Rhythm DiScrimination

Find Trials by Condition in Boston

Early Diagnosis of Candidiasis in Premature Infants

Group-based Peer Support Versus Individual Education for Patients Undergoing CPAP Treatment

Study of Oral IXAZOMIB in Combination With Lenalidomide and Dexamethasone in Participants With Newly Diagnosed Multiple Myeloma

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Supporting Use of AC Through Provider Profiling of Oral AC Therapy for AF

A Brief Educational Intervention to Improve Traumatic Brain Injury (TBI) Screening Outcomes

Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer

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Observational Study of Surgical Treatment of Necrotizing Enterocolotis

Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage

Investigational Device Exemption Study to Determine the Safety and Efficacy of the Astron and Pulsar Stents

Omadacycline Versus Linezolid for the Treatment of ABSSSI (EudraCT #2013-003644-23)

Long-term Safety and Tolerability of Atacicept (Long-term Follow-Up of Participant Who Participated in ADDRESS II)

FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer

A Phase I/IIa Open-Label, Dose Escalation and Cohort Expansion Trial of Oral TSR-011 in Patients With Advanced Solid Tumors and Lymphomas

The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions in Small Vessels

PLATINUM Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions-Pharmacokinetics (PLATINUM PK)

Phase IV EORTC Quality of Life Module for Patients With Chronic Myeloid Leukemia