Clinical Trials in Boston

Showing 10981-11000 of 17,836 trials

Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma

NCT01476410

This phase II trial studies how well giving brentuximab vedotin together with combination chemotherapy works in treating older patients with previously untreated stage II-IV Hodgkin lymphoma (HL). Monoclonal antibody-drug conjugates, such as brentuximab vedotin, can block cancer growth in different ways by targeting certain cells. Drugs used in chemotherapy, such as doxorubicin hydrochloride, vinblastine, and dacarbazine (AVD), work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving brentuximab vedotin, doxorubicin hydrochloride, vinblastine, and dacarbazine together may kill more cancer cells.

Adult Lymphocyte Depletion Hodgkin LymphomaAdult Lymphocyte Predominant Hodgkin LymphomaAdult Mixed Cellularity Hodgkin Lymphoma+4 more

Northwestern University48 participantsStarted Nov 2011

Stanford, California, United States • Chicago, Illinois, United States • Chicago, Illinois, United States +4 more locations

COMPLETEDPhase 2< 1 mile

A Study of Subcutaneous Abatacept to Treat Diffuse Cutaneous Systemic Sclerosis

NCT02161406

The study hypothesis is that SC abatacept is safe and shows evidence of efficacy (improvement in modified Rodnan score \[mRSS\]) in patients with diffuse cutaneous systemic sclerosis (dcScc) compared to matching placebo.

Diffuse Cutaneous Systemic Sclerosis

Dinesh Khanna, MD, MS88 participantsStarted Sep 2014

Los Angeles, California, United States • Los Angeles, California, United States • Redwood City, California, United States +24 more locations

Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma

A Study of Subcutaneous Abatacept to Treat Diffuse Cutaneous Systemic Sclerosis

Find Trials by Condition in Boston

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma

TDCS to Improve Motivation and Memory in Elderly (TIME)

Assessment of Ventilatory Management During General Anesthesia for Robotic Surgery

Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy

A Study Evaluating the Safety of Escalating Doses of DLYE5953A in Patients With Refractory Solid Tumors

Imatinib Treatment in Recent Onset Type 1 Diabetes Mellitus

FOLFOX +/- Ziv-Aflibercept for Esophageal and Gastric Cancer

Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma

Opioid-induced Bowel Dysfunction (OBD) Pivotal Assessment of Lubiprostone (OPAL)

Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders (AIM-PC)

Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer.

The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade Glioma

Dose-ranging Study in Patients With Type 1 Diabetes Mellitus

A Study of ALKS 3831 in Adults With Schizophrenia (The ENLIGHTEN-2 Study)

Clinical Evaluation of a Test for Monitoring the Recurrence of Bladder Cancer

Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction

Neocate In Infants and Children With Complex Conditions

A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State