Clinical Trials in Boston

Showing 9981-10000 of 17,836 trials

Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)

NCT03168711

This is a multi-center, 20-week study of inosine treatment. Study Objectives and Endpoints The primary objective of the study is to determine the safety and tolerability of oral administration of inosine (administered daily) dosed to moderately elevate serum urate over 20 weeks. The primary outcome measures will be 1. Safety, as measured by adverse events 2. Tolerability, defined as the ability of subjects to complete the entire 20-week study. As an exploratory objective, we will test the feasibility and utility of a smartphone application for monitoring symptoms and disease progression in patients with amyotrophic lateral sclerosis (ALS).

Amyotrophic Lateral Sclerosis

Massachusetts General Hospital48 participantsStarted Oct 2017

Fort Lauderdale, Florida, United States • Boston, Massachusetts, United States • Minneapolis, Minnesota, United States

COMPLETEDPhase 3< 1 mile

A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)

NCT02292537

The primary objective of this study is to examine the clinical efficacy of nusinersen (ISIS 396443) administered intrathecally to participants with later-onset Spinal Muscular Atrophy (SMA). The secondary objective is to examine the safety and tolerability of nusinersen administered intrathecally to participants with later-onset SMA.

Spinal Muscular Atrophy

Biogen126 participantsStarted Nov 2014

Los Angeles, California, United States • Palo Alto, California, United States • Aurora, Colorado, United States +21 more locations

Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)

A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)

Find Trials by Condition in Boston

A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma

Personalized CRT - MPP Post Approval Study

Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial

An Expert System to Reduce Depression in Primary Care

A 12-week, Randomized, Double-masked, Parallel Group Comparison of Evening Dosing With Xalacom in Subjects With Glaucoma

Phase 3 Papulopustular Rosacea Study

Clinical Study to Test the Efficacy and Safety of Adapalene, 0.1%

To Evaluate the Safety and Effectiveness of Atorvastatin Plus a Cholinesterase Inhibitor in AD Patients.

A Study to Assess the Safety and Tolerability of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA).

Model 4396 Left Ventricular (LV) Lead Chronic Performance Study

Adapalene-BPO Gel Associated With Doxycycline Hyclate 100 mg in the Treatment of Severe Acne Vulgaris

Efficacy and Safety of Pazopanib Monotherapy After First Line Chemotherapy in Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

A Study Evaluating ABI-H0731 as Adjunctive Therapy in Participants With Chronic Hepatitis B Infection

Establish The Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets (ACTFAST)

Canadians Achieve Cholesterol Targets Fast With Atorvastatin Stratified Titration

AIR Extension Study - Long-Term Safety of Alair Treated Subjects

Epiduo Pediatric Acne Study

Comparison of Epiduo Associated With Lymecycline Versus Epiduo Vehicle Associated With Lymecycline in Acne Vulgaris