Clinical Trials in Boston

Showing 9361-9380 of 17,836 trials

Dose Escalation Study of UCART19 in Adult Patients With Relapsed / Refractory B-cell Acute Lymphoblastic Leukaemia

NCT02746952

The study is in two parts: a dose escalation then a safety dose expansion. The purpose of the dose escalation part is to evaluate the safety and tolerability of ascending doses of UCART19 (dose-escalation part) given as a single infusion in patients with relapsed / refractory (R/R) B-cell acute lymphoblastic leukaemia (B-ALL), to determine the maximum tolerated dose (MTD), the recommended dose and the lymphodepletion regimen. The purpose of the safety dose expansion is to assess the safety and tolerability of the RD for UCART19.

B-cell Acute Lymphoblastic Leukemia

Institut de Recherches Internationales Servier25 participantsStarted Aug 2016

Boston, Massachusetts, United States • Philadelphia, Pennsylvania, United States • Houston, Texas, United States +6 more locations

UNKNOWNPhase 2/3< 1 mile

Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer

NCT02065687

This randomized phase II/III trial studies how well paclitaxel, carboplatin, and metformin hydrochloride works and compares it to paclitaxel, carboplatin, and placebo in treating patients with endometrial cancer that is stage III, IV, or has come back. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Metformin hydrochloride may help paclitaxel and carboplatin work better by making cancer cells more sensitive to the drugs. It is not yet known whether paclitaxel and carboplatin is more effective with or without metformin hydrochloride in treating endometrial cancer.

Endometrial AdenocarcinomaEndometrial Clear Cell AdenocarcinomaEndometrial Serous Adenocarcinoma+9 more

Gynecologic Oncology Group469 participantsStarted Mar 2014

Birmingham, Alabama, United States • Huntsville, Alabama, United States • Phoenix, Arizona, United States +428 more locations

Dose Escalation Study of UCART19 in Adult Patients With Relapsed / Refractory B-cell Acute Lymphoblastic Leukaemia

Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer

Find Trials by Condition in Boston

Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE)

Post-Approval Clinical Study of the Talent Thoracic Stent Graft to Treat Thoracic Aortic Aneurysms (THRIVE)

A Study of Alectinib in RET-rearranged Non-small Cell Lung Cancer or RET-mutated Thyroid Cancer

Study of Tesevatinib Monotherapy in Patients With Recurrent Glioblastoma

Virtual Visits at Brigham and Women's Hospital

Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)

A First-in-Human Study of RPT193 in Healthy Volunteers and Patients With Atopic Dermatitis

I-ZIP Ocular Bandage Pivotal Study

Evaluation of the Safety, Effectiveness & Usability of the XACT Robotic System for Image Guided Percutaneous Procedures

Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed, Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer

Delayed Cord Clamping and Infant Brain Study

Hand Holding During Light Sedation for Minimally Invasive Spine Surgery Improves Outcomes

A PALG Prospective Multicenter Clinical Trial to Compare the Efficacy of Two Standard Induction Therapies (DA-90 vs DAC) and Two Standard Salvage Regimens (FLAG-IDA vs CLAG-M) in AML Patients ≤ 60 Years Old

Study of RV001V in Biochemical Failure Following Curatively Intended Therapy For Localized Prostate Cancer

The Designer D-dimer Deep Vein Thrombosis Diagnosis (4D) Study

Clinical Evaluation of ExoDx Prostate(IntelliScore) in Men Presenting for Initial Prostate Biopsy

Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study)

Impact of COVID-19 Pandemic in Perinatal Mental Health (RISEUP-PPD-COVID-19)