Clinical Trials in Boston

Showing 8121-8140 of 17,836 trials

The Effects of Acute Weight Gain and Acute Calorie Deprivation on Marrow Adipose Tissue

NCT02482519

Marrow adipocytes have been identified as a component of the bone marrow micro-environment. Evidence exists suggesting that marrow fat plays an important physiologic role in both bone mineral and energy metabolism in humans. The investigators will study the effects of acute weight gain and acute nutritional deprivation on energy homeostasis and bone mineral metabolism by examining marrow adiposity, peripheral fat depots and bone microarchitecture. The study will include two ten day inpatient study visits. Participants will eat a high calorie diet for 10 days, followed by a 13-18 day stabilization period at home, and then return for a ten day fast.

Healthy

Massachusetts General Hospital28 participantsStarted Nov 2015

Boston, Massachusetts, United States

UNKNOWNPhase 3< 1 mile

Ravulizumab and COVID-19

NCT04570397

Ultomiris (Ravulizumab), is a monoclonal antibody that specifically targets terminal complement products and is proposed for the treatment of COVID-19 induced microvasculature injury and endothelial damage leading to thrombotic microangiopathy (TMA) causing acute kidney injury (AKI). Ravulizumab is to be used for participants with a confirmed diagnosis of COVID-19 who clinically or diagnostically present with deteriorating renal function. Ravulizumab causes immediate and sustained inhibition of the terminal complement cascade. The use of ravulizumab could ameliorate COVID-19 induced kidney injury due to TMA, shorten hospital stay, and improve the overall survival.

Covid19Thrombotic MicroangiopathiesAcute Kidney Injury

Brigham and Women's Hospital32 participantsStarted Dec 2020

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement

NCT05669066

The main purpose of this study is to look at whether meditation techniques can help reduce pain and opioid use after surgery.

Arthropathy of KneeOsteo Arthritis KneeOsteonecrosis+7 more

Beth Israel Deaconess Medical Center29 participantsStarted Jul 2017

Boston, Massachusetts, United States

The Effects of Acute Weight Gain and Acute Calorie Deprivation on Marrow Adipose Tissue

Ravulizumab and COVID-19

Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement

Find Trials by Condition in Boston

Trial on Endovascular Aneurysm Management

Addition of X4P-001 to Nivolumab Treatment in Participants With Renal Cell Carcinoma

OLAParib COmbinations

Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI

REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects

Electronic Symptom Monitoring Intervention for Hospitalized Patients With Cancer

Solius UV Light Source in Improving Serum Levels of 25-hydroxyvitamin D

Neuromodulation of Lidocaine Cream Effect on Chronic Pain Patients

Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma

Study Evaluating Efficacy and Safety of FFX Versus Combination of CPI-613 With mFFX in Patients With Metastatic Adenocarcinoma of the Pancreas

Initiating and Maintaining Physical Activity in Depressed Individuals

A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Uncontrolled Severe Asthma

Efficacy and Safety of Farletuzumab (MORAb-003) in Combination With Carboplatin and Taxane in Participants With Platinum-sensitive Ovarian Cancer in First Relapse

A Study of Venetoclax and Dinaciclib (MK7965) in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Validation of Dyskinesia Rating Scales

Long-term, Open-label, Flexible-dose, Extension Study of Vortioxetine in Child and Adolescent Participants With Major Depressive Disorder (MDD) From 7 to 18 Years of Age

A Rollover Study to Provide Continued Treatment With Eltrombopag