Clinical Trials in Boston

Showing 7601-7620 of 17,836 trials

Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101)

NCT02584634

The purpose of this study is to evaluate the safety and efficacy of avelumab when combined with either crizotinib or PF-06463922.

Non-Small Cell Lung Cancer

Pfizer43 participantsStarted Dec 2015

Atlanta, Georgia, United States • Atlanta, Georgia, United States • Atlanta, Georgia, United States +17 more locations

COMPLETEDPhase 2< 1 mile

BLP25 Liposome Vaccine and Bevacizumab After Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Stage IIIA or Stage IIIB Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

NCT00828009

RATIONALE: Vaccines may help the body build an effective immune response to kill tumor cells. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving vaccine therapy together with bevacizumab after chemotherapy and radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving BLP25 liposome vaccine together with bevacizumab after chemotherapy and radiation therapy in treating patients with newly diagnosed stage IIIA or stage IIIB non-small cell lung cancer that cannot be removed by surgery.

Lung Cancer

ECOG-ACRIN Cancer Research Group70 participantsStarted Jan 2011

Palo Alto, California, United States • Stanford, California, United States • Macon, Georgia, United States +85 more locations

Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101)

BLP25 Liposome Vaccine and Bevacizumab After Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Stage IIIA or Stage IIIB Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

Find Trials by Condition in Boston

A Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

Gemcitabine With or Without Radiation Therapy in Treating Patients With Pancreatic Cancer

A Study in Adult Patients With Type I, III or IV Osteogenesis Imperfecta Treated With BPS804

Surveillance Trial to Evaluate a Shortened Infusion Time of Intravenous Ibuprofen

Selenium in Preventing Tumor Growth in Patients With Previously Resected Stage I Non-small Cell Lung Cancer

Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe Pruritus

Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-Risk Stage II, Stage III, or Stage IV Follicular Lymphoma

A Study to Evaluate the Safety of STS101 in the Acute Treatment of Migraine

Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer

Emergency Department Outcomes for Patients With Opioid Use Disorder

Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue (WATER)

Bucillamine in Treatment of Patients With COVID-19

Phase III Study of AZD7442 for Treatment of COVID-19 in Outpatient Adults

MP1032 Treatment in Patients With Moderate to Severe COVID-19

Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study

RBN-2397 in Combination With Pembrolizumab in Patients With SCCL

Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp

Adrenal Suppression and Absorption Study of Halobetasol Propionate Foam in Subjects 12-17 With Plaque Psoriasis