Clinical Trials in Boston

Showing 681-700 of 15,299 trials

ctDNA in Cutaneous Squamous Cell Carcinoma

NCT06875609

The purpose of this study is to test the potential for a liquid biopsy assay to detect residual disease after surgery in patients with cutaneous squamous cell carcinoma as well as the potential for this assay to monitor response to immunotherapy treatment.

Cutaneous Squamous Cell Carcinoma

Massachusetts Eye and Ear Infirmary60 participantsStarted Mar 2025

Boston, Massachusetts, United States

RECRUITINGNA< 1 mile

A Trial of Hydrus Microstent Versus Goniotomy

NCT06289491

The goal of this clinical trial is to evaluate the comparative efficacy and safety of Hydrus Microstent, incisional goniotomy, and excisional goniotomy when combined with cataract surgery in patients with mild and moderate open-angle glaucoma. The main questions it aims to answer are: * How do the intraocular pressure lowering effects of these three microinvasive glaucoma surgeries compare? * How do the safety profiles of these three microinvasive glaucoma surgeries compare? Participants will be randomized to one of these three microinvasive glaucoma surgeries in combination with cataract surgery.

GlaucomaGlaucoma, Open-Angle

Massachusetts Eye and Ear Infirmary243 participantsStarted Feb 2025

Boston, Massachusetts, United States

RECRUITINGNA< 1 mile

Speech Treatment for Minimally Verbal Children With ASD and CAS

NCT05066178

Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This study tests whether CAS-specific treatment, appropriately modified for minimally verbal children with autism, improves their speech.

Developmental Verbal DyspraxiaAutism Spectrum Disorder

MGH Institute of Health Professions20 participantsStarted May 2024

Boston, Massachusetts, United States

ctDNA in Cutaneous Squamous Cell Carcinoma

A Trial of Hydrus Microstent Versus Goniotomy

Speech Treatment for Minimally Verbal Children With ASD and CAS

Find Trials by Condition in Boston

Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis

Questionnaire and Tissue Banking For Multiple Myeloma, Waldenstrom Macroglobulinemia and Related Disorders

Immune and Genomic Markers in ALK+ NSCLC

A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

Personalized Performance Optimization Platform

A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight

AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy.

A Platform Study in Non-Small Cell Lung Cancer (NSCLC)

Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer

A Study to Evaluate Safety and Preliminary Anti-tumor Activity of Debio 0123 as Monotherapy in Adult Participants With Advanced Solid Tumors

A Study to Learn About Medicine Called Ritlecitinib in Children Aged Between 6 to 12 Years With Severe Alopecia Areata

177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer

A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis

Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis

A Study to Provide Continued Access to Mitapivat for Participants Who Previously Completed an Agios-Sponsored Mitapivat Study

A Study to Evaluate the Immune Response and Safety of an Influenza Vaccine in Adults 18 Years of Age and Above