Clinical Trials in Boston

Showing 5641-5660 of 17,836 trials

Safety & Immunogenicity of JNJ-64041757, Live-attenuated Double-deleted Listeria Immunotherapy, in Subjects With Non Small Cell Lung Cancer

NCT02592967

The purpose of this study is to determine the recommended Phase 2 dose (RP2D) of JNJ-64041757 a live attenuated double deleted (LADD) Listeria monocytogenes (bacteria in which two virulence genes, which encode molecules that help cause disease, have been removed) when administered intravenously to participants with advanced (Stage IIIb) or metastatic (Stage IV) NSCLC (adenocarcinoma).

Carcinoma, Non-Small-Cell Lung

Janssen Research & Development, LLC18 participantsStarted Dec 2015

Duarte, California, United States • Baltimore, Maryland, United States • Bethesda, Maryland, United States +6 more locations

COMPLETEDNA< 1 mile

Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)

NCT04479787

The objective of this study is to evaluate the efficacy of BurstDR dorsal column stimulation, compared with conventional medical management, in improving pain and back-related physical function in subjects suffering with chronic, refractory axial low back pain with a neuropathic component, who have not had lumbar spine surgery and for whom surgery is not an option.

Chronic Low-Back PainRefractory PainNeuropathic Pain

Abbott Medical Devices270 participantsStarted Jul 2020

Phoenix, Arizona, United States • Tucson, Arizona, United States • Camarillo, California, United States +27 more locations

Safety & Immunogenicity of JNJ-64041757, Live-attenuated Double-deleted Listeria Immunotherapy, in Subjects With Non Small Cell Lung Cancer

Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)

Find Trials by Condition in Boston

A Study of Guselkumab in Participants With Familial Adenomatous Polyposis

Cabozantinib and Nivolumab for Carcinoid Tumors

HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy

Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)

Evaluation of Flash Continuous Glucose Monitoring to Reduce Hyperglycemia in People With T2 Diabetes

Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)

Optimizing tDCS to Improve Dual Task Gait and Balance

A Natural History Study of Biomarkers and Clinical Outcomes in Mucopolysaccharidosis Type IIIA (MPS IIIA; Sanfilippo Syndrome)

PhII ICb With/Without Erbitux in MBC Pts

A Study of Loncastuximab Tesirine and Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Participants With Diffuse Large B-cell Lymphoma (DLBCL)

Study of the Safety, Tolerability, Pharmacokinetics and Biomarker of DONQ52 in Celiac Disease Patients

Avelumab in First-line NSCLC (JAVELIN Lung 100)

The ShortCut™ Study Protocol

Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS)

A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

A Study on the Immune Response and Safety of an Adjuvanted Human Papillomavirus Vaccine When Given to Healthy Women 16 to 26 Years of Age

A Study of Subcutaneously-administered Guselkumab Delivered by 3 Different Devices in Healthy Participants

PMCF Study on the Safety, Performance and Clinical Benefits Data of the ToggleLoc™ 2.9mm in the Elbow