Clinical Trials in Boston

Showing 5381-5400 of 17,836 trials

Exercise Training in Transthyretin Cardiac Amyloidosis

NCT05797857

Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patients on optimal treatment for transthyretin cardiac amyloidosis. This is a vital next step to improve functional capacity and quality of life of people suffering from transthyretin cardiac amyloidosis.

Amyloid CardiomyopathyTransthyretin Cardiac Amyloidosis

Brigham and Women's Hospital40 participantsStarted Jul 2024

Boston, Massachusetts, United States

COMPLETEDPhase 3< 1 mile

APR-246 & Azacitidine for the Treatment of TP53 Mutant Myelodysplastic Syndromes (MDS)

NCT03745716

A Phase III, multicenter, randomized study to compare the rate of complete response (CR) and duration of CR, in patients with TP53-mutated MDS who will receive APR-246 and azacitidine or azacitidine alone.

MDS

Aprea Therapeutics154 participantsStarted Jan 2019

Duarte, California, United States • Palo Alto, California, United States • New Haven, Connecticut, United States +24 more locations

Exercise Training in Transthyretin Cardiac Amyloidosis

APR-246 & Azacitidine for the Treatment of TP53 Mutant Myelodysplastic Syndromes (MDS)

Find Trials by Condition in Boston

PF-06863135 As Single Agent And In Combination With Immunomodulatory Agents In Relapse/Refractory Multiple Myeloma

Safety, Tolerability and Immune Effects of the Nasal Foralumab in Healthy Human Volunteers

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer

A Study of Etigilimab and Nivolumab in Participants With Locally Advanced or Metastatic Tumors

p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis

Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder

The TRANQUILITY 2 Trial: A Phase 3 Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease

A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases

A Study of LY3561774 in Participants With Mixed Dyslipidemia

A Study of INCB050465 in Relapsed or Refractory Follicular Lymphoma

A Study of BMS-986442 With Nivolumab With or Without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer

Observational Study of Canadian Patients (6 Years or Older) Receiving Dupixent® for Moderate to Severe Atopic Dermatitis

Study to Compare 2 Botulinum Type A Toxins in the Treatment of Glabellar Frown Lines

Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5410 in Adult Participants 18 Years of Age and Older

Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT411

A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure