Clinical Trials in Boston

Showing 5321-5340 of 17,836 trials

Early Intervention in High Risk CCUS

NCT06802146

This research is being done to find out more about the potential risks and benefits of early treatment in participants with high risk Clonal Cytopenia of Unknown Significance (CCUS). This study will give eligible CCUS participants the option of either being observed or taking an oral drug as treatment. The names of the study drug involved in this study is: -Decitabine/cedazuridine (DEC/CED) (a nucleoside metabolic inhibitor and cytidine deaminase inhibitor).

Clonal Cytopenia of Undetermined SignificanceCytopenia

Lachelle D. Weeks, MD, PhD108 participantsStarted Feb 2025

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

Kids FACE FEARS Comparative Effectiveness Research

NCT03707158

The Kids FACE FEARS (Kids Formats of Anxiety Care Effectiveness study For Extending the Acceptability and Reach of Services) is a large-scale, streamlined, pragmatic Randomized Controlled Trial (RCT) evaluating Therapist-Led CBT (telehealth, office-based, or hybrid) vs. Guided Online Cognitive-Behavioral Therapy (CBT) for the treatment of elevated child and adolescent anxiety. Families will be recruited from pediatric health centers serving primarily racial/ethnic minority youth in urban, suburban, and semi-rural regions. Services will be offered in English and Spanish. Patient-centered outcomes will be evaluated across a one-year follow-up period. To compare the effectiveness of the two treatment comparators, investigators will analyze the reports of caregivers, youth, and therapists, as well as independent evaluators who are not informed of each child's treatment assignment. Primary outcomes will focus on family-rated anxiety severity and impairment, treatment responder and remission status rated by independent evaluators, family-perceived effectiveness, and treatment satisfaction. Secondary analyses will examine additional outcomes, predictors of varied outcomes across different subgroups of youth, and facilitators and barriers to treatment implementation. Caregivers, patients, providers, and other key stakeholders will be actively engaged throughout all aspects of the research.

Child AnxietyAnxiety DisordersAnxiety+3 more

Boston Medical Center305 participantsStarted Oct 2019

Miami, Florida, United States • Miami, Florida, United States • Baltimore, Maryland, United States +5 more locations

Early Intervention in High Risk CCUS

Kids FACE FEARS Comparative Effectiveness Research

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Efficacy of Emotionally Focused Therapy Among Spanish Speaking Couples

Study to Investigate Hepatic Impairment on PK, Safety, Tolerability of Camizestrant in Post-Menopausal Female Subjects