Clinical Trials in Boston

Showing 5121-5140 of 17,836 trials

Study of AGEN1571 in Participants With Advanced Solid Tumors

NCT05377528

This is an open-label, Phase 1, 2-part trial to determine recommended phase 2 doses (RP2Ds) and evaluate the safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of AGEN1571 both as a monotherapy and in combination with balstilimab (PD-1 inhibitor) and/or botensilimab (2-agent combination or 3-agent combination) in participants diagnosed with advanced solid tumors. Part 1 will be the dose escalation phase to determine the RP2D of AGEN1571 monotherapy or AGEN1571 in combination with balstilimab and/or botensilimab. Part 2 will be the dose expansion phase for specific disease indications. Participants will receive study treatment for up to 2 years, or until any disease progression, unacceptable toxicity, or participant wishes to withdraw consent for any reason.

Advanced Solid Tumor

Agenus Inc.22 participantsStarted Jul 2022

Los Angeles, California, United States • Denver, Colorado, United States • Sarasota, Florida, United States +3 more locations

COMPLETEDPhase 2< 1 mile

A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome

NCT04129164

The purpose of the study is to evaluate the efficacy, safety, and tolerability of VIB4920 (formerly MEDI4920) in adult participants with Sjögren's Syndrome (SS).

Sjögren's Syndrome

Amgen183 participantsStarted Dec 2019

Fullerton, California, United States • Upland, California, United States • Lawrenceville, Georgia, United States +59 more locations

Study of AGEN1571 in Participants With Advanced Solid Tumors

A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome

Find Trials by Condition in Boston

Myo-inositol During Pregnancy to Prevent Gestational Diabetes

A Study of Paliperidone Palmitate 6-Month Formulation

A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)

A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression

Effect of Black Cumin Seed Oil Supplementation on Cortisol, Stress and Mood

Expanded Access for Cancer Treatment With Balstilimab (AGEN2034) and Zalifrelimab (AGEN1884)

Image-Guided Radiosurgery or Stereotactic Body Radiation Therapy in Treating Patients With Localized Spine Metastasis

A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression

An Efficacy and Safety Study of Sirukumab in Participants With Major Depressive Disorder

A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens

54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide

A Study of Ustekinumab in Participants With Active Systemic Lupus Erythematosus

ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES

A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy

Study of Dabrafenib+Trametinib in the Adjuvant Treatment of Stage III BRAF V600+ Melanoma After Complete Resection to Evaluate the Impact on Pyrexia Related Outcomes

A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(Alpha) Refractory Participants With Active Radiographic Axial Spondyloarthritis

Safety, Tolerability and Efficacy of ACZ885 on Leg Artery Structure in Patients With Peripheral Artery Disease

An Investigation to Validate Speech Perception Assessment for Adult Cochlear Recipients Using a Mobile Research App