Clinical Trials in Boston

Showing 4021-4040 of 17,836 trials

Guideline Directed Medical Therapy in Patients With Heart Failure

NCT06700213

The TEAM-MGH study will formerly evaluate impact of the GDMT Clinic versus matched usual care patients on the proportion of GDMT administration over a 12 week period in approximately 300 total patients with HF across the spectrum of LVEF (with a minimum of 150 with HFrEF). The study will also assess impact of the GDMT Clinic on health status, functional capacity, biomarker profiles, cardiac remodeling and cardiovascular events.

Heart Failure

Massachusetts General Hospital300 participantsStarted Sep 2023

Boston, Massachusetts, United States

Active Not Recruiting< 1 mile

Multimodal Machine Learning Characterization of Solid Tumors

NCT04687969

This research study wants to develop advanced imaging methods to more accurately characterize prostate cancer or solid tumor aggressiveness. This observational study involves \[18F\]DCFPyL positron emission tomography and magnetic resonance imaging (PET/MRI)

Adenocarcinoma of ProstateRadical ProstatectomyHepatocellular Carcinoma (HCC)+3 more

Ciprian Catana, MD, PhD135 participantsStarted Oct 2022

Boston, Massachusetts, United States • Boston, Massachusetts, United States

COMPLETEDPhase 2< 1 mile

Study of OCA in Combination With BZF Evaluating Efficacy, Safety and Tolerability in Participants With PBC

NCT05239468

Study to determine the effect of the investigational drug bezafibrate (BZF) alone and in combination with the investigational drug obeticholic acid (OCA) in participants with Primary Biliary Cholangitis (PBC).

Primary Biliary Cholangitis

Intercept Pharmaceuticals72 participantsStarted Mar 2022

Birmingham, Alabama, United States • Coronado, California, United States • Mission Hills, California, United States +23 more locations

Guideline Directed Medical Therapy in Patients With Heart Failure

Multimodal Machine Learning Characterization of Solid Tumors

Study of OCA in Combination With BZF Evaluating Efficacy, Safety and Tolerability in Participants With PBC

Find Trials by Condition in Boston

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery

A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

Comparing Hypothermic Temperatures During Hemiarch Surgery

Computerized Registry of Patients With Venous Thromboembolism (RIETE)

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

Investigational Extended Wear Insulin Infusion Set in People With Type 1 Diabetes

Optimizing Rehabilitation for Phantom Limb Pain Using Mirror Therapy and Transcranial Direct Current Stimulation (tDCS)

Development of a Training Intervention to Improve Mental Health Treatment Effectiveness and Engagement for Youth With Documented Mental Health Disparities

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2

A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium

A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF)

A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation

A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis

Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors