Clinical Trials in Austin

Showing 12921-12940 of 15,205 trials

Dose Escalation, MTD, Safety and PK Study of a Single Dose SC Injection of TransCon PEG Treprostinil in Healthy Male Volunteers

NCT02149095

TransCon PEG treprostinil is a novel prodrug form of treprostinil, in which treprostinil is reversibly conjugated via a four-arm branched polyethylene glycol (PEG) molecule. Reversible coupling of treprostinil to PEG should allow for a modified extended pharmacokinetic profile to achieve sustained plasma concentrations of treprostinil. This will be the first investigation of TransCon PEG treprostinil in humans. This study aims to determine the maximum tolerated dose (MTD) and assess the safety, tolerability and pharmacokinetics of escalating single doses of a subcutaneous injection of TransCon PEG treprostinil.

PAH

United TherapeuticsStarted Jul 2014

Austin, Texas, United States

COMPLETED< 1 mile

Gene Testing to Help in the Diagnosis and Treatment of Childhood Brain Tumors

NCT00003096

RATIONALE: Analyzing the number and structure of genes found in a child's cancer cells may help doctors improve methods of diagnosing and treating children with brain tumors. PURPOSE: This clinical trial is studying the number and structure of genes in cancer cells of children with brain tumors.

Brain TumorsCentral Nervous System Tumors

Children's Oncology Group88 participantsStarted Dec 1996

Phoenix, Arizona, United States • Downey, California, United States • Loma Linda, California, United States +58 more locations

Dose Escalation, MTD, Safety and PK Study of a Single Dose SC Injection of TransCon PEG Treprostinil in Healthy Male Volunteers

Gene Testing to Help in the Diagnosis and Treatment of Childhood Brain Tumors

Find Trials by Condition in Austin

Treatment Protocol for the Use of Sorafenib in Patients With Advanced Renal Cell Carcinoma

A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depression

Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma

Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line Therapy

A Phase 3 Study of Telaprevir in Combination With Pegasys® and Copegus® in Treatment-Naive Subjects With Genotype 1 Hepatitis C Virus (HCV)

A Study of Telaprevir (VX-950), Pegasys and Copegus in Hepatitis C (PROVE3)

A Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients With Malignant Glioma

A Phase 1, Open-Label, Dose Escalation Study of ANG1005 in Patients With Advanced Solid Tumors and Metastatic Brain Cancer

Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma

A Study of IMC-1121B (Ramucirumab) With or Without Dacarbazine in Metastatic Malignant Melanoma

Safety and Efficacy Study of Ceftaroline in Subjects With Staphylococcus Aureus Bacteremia or With Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia

Efficacy and Safety of Palonosetron Intravenous in Prevention of Chemotherapy Induced Nausea and Vomiting in Pediatric Patients

Oxygen Monitoring of Patients After Surgery on the Hospital General Care Floor

ADenosine Vasodilator Independent Stenosis Evaluation II - ADVISE II

Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer

An Extension to Study MA21573, Evaluating Tocilizumab in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biological DMARDs and/or Anti-tumor Necrosis Factor (TNF) Therapy

A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema

A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema