Ulcerative Colitis Clinical Trials

Showing 6281-6300 of 9,572 trials

Hypnosis to Perform Awake Intubation

NCT02513511

Awake intubation is a recommended safety procedure in specific cases where the intubation or ventilation before general anesthesia is at risk. Numerous techniques to allow awake intubation have been described, such as pure awake technique, local anesthetics or intravenous sedation for example. Hypnosis is used for various operating room techniques and surgeries. The investigators aim to analyze the feasibility of awake laryngoscopy and intubations on patients placed under hypnosis alone.

Nasal Obstruction

University of Lausanne Hospitals30 participantsStarted Aug 2015

Lausanne, Canton of Vaud, Switzerland

COMPLETEDPhase 3

BMN 110 Phase 3B in Australian Patients

NCT01966029

There is currently no treatment for MPS IVA other than supportive care for the clinical manifestations of the disease. Enzyme replacement therapy (ERT) with BMN 110 to replace the deficient GALNS is a potential new treatment option for MPS IVA patients. BMN 110, containing recombinant human GALNS (rhGALNS) developed by BioMarin is expected to reduce the progressive, pathologic accumulation of KS, and improve signs and symptoms of the disease. The objective of this Phase 3B open label study (110-502) will be to evaluate the safety and tolerability of 2.0 mg/kg/week (qw) of BMN 110 in Australian patients with MPS IVA. In addition, a number of secondary and tertiary efficacy endpoints will also be investigated. The dose and regimen of BMN 110 have been selected on the basis of data from a Phase 1/2 clinical study with BMN 110, nonclinical and in vitro studies with BMN 110, and clinical and nonclinical data from other enzyme replacement therapies. Extension Phase is included per amendment dated 10Mar 2014: To provide patients enrolled in the Initial Phase access to BMN 110 until commercial product becomes available in Australia and continue to assess long-term safety

Mucopolysaccharidosis IVA (Morquio A Syndrome)

BioMarin Pharmaceutical13 participantsStarted Jul 2013

Westmead, New South Wales, Australia • Brisbane, Queensland, Australia • Melbourne, Victoria, Australia +2 more locations

Hypnosis to Perform Awake Intubation

BMN 110 Phase 3B in Australian Patients

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