Rheumatoid Arthritis Clinical Trials in Philadelphia

Showing 21-40 of 3,347 trials

Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial

NCT04565119

BioBOOST is a multicenter, observational study of the effect of derangements in brain physiologic parameters on brain injury biomarker levels in patients with severe traumatic brain injury.

TBI (Traumatic Brain Injury)

University of Pennsylvania300 participantsStarted Dec 2020

Ann Arbor, Michigan, United States • Philadelphia, Pennsylvania, United States

Active Not RecruitingPhase 2< 1 mile

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

NCT04439175

This phase II MATCH treatment trial identifies the effects of GDC-0032 (taselisib) in patients whose cancer has a genetic change called PIK3CA mutation. Taselisib may stop the growth of cancer cells by blocking PIK3CA, a protein that may be needed for cell growth. Researchers hope to learn if taselisib will shrink this type of cancer or stop its growth.

Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more

National Cancer Institute (NCI)70 participantsStarted Feb 2016

Philadelphia, Pennsylvania, United States

TERMINATEDPhase 2< 1 mile

PR3-AAV Resilient Remission or PRRR

NCT05376319

The purpose of this study is to evaluate the efficacy and safety of obinutuzumab for the treatment of proteinase 3 Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis (PR3-AAV).

Granulomatosis With PolyangiitisMicroscopic PolyangiitisANCA Associated Vasculitis

Mayo Clinic6 participantsStarted Jun 2023

Boston, Massachusetts, United States • Rochester, Minnesota, United States • Philadelphia, Pennsylvania, United States

RECRUITING< 1 mile

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

NCT06465810

The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and outcomes. In addition, information on the effectiveness of ATTR amyloidosis treatments, including eplontersen, which is a ligand-conjugated antisense oligonucleotide gene silencing treatment targeting activity against both the mutant and wild-type TTR protein, will be collected.

Transthyretin AmyloidosisATTR-CMATTRv-PN+3 more

AstraZeneca1,850 participantsStarted Jun 2024

La Jolla, California, United States • Los Angeles, California, United States • San Francisco, California, United States +57 more locations

Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

PR3-AAV Resilient Remission or PRRR

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Rheumatoid Arthritis Trials in Other Cities

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

DESTINY-PANTUMOUR04

A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)

Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

Evaluate the Safety and Effectiveness of the Polymotion Hip Resurfacing (PHR) System Compared to Total Hip Arthroplasty

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia

A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers

Other Conditions in Philadelphia