Heart Disease Clinical Trials

Showing 2381-2400 of 7,313 trials

LEft Bundle branchArea Pacing to Avoid Pacing-induced CARdiomyopathy

NCT05910866

LEAP-CAR will evaluate the benefit of left bundle branch area pacing (LBBAP), comparing to conventional right ventricular pacing (RVP), in preventing pacing-induced cardiomyopathy (PICM) in patients undergoing pacemaker implant for advanced (2° or 3° degree) atrioventricular block, with baseline left ventricular ejection fraction (LVEF) \>45%. LEAP-CAR is a randomized, prospective, double blind clinical trial.

BradycardiaHeart FailurePacemaker-Induced Cardiomyopathy+2 more

Azienda Ospedaliero Universitaria Maggiore della Carita130 participantsStarted Jun 2023

Novara, Italy

COMPLETEDPhase 1/2

Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial)

NCT04125732

The primary purpose of this trial is to determine the safety of XC001 (AdVEGFXC1) in patients who suffer from angina caused by coronary artery disease and have no other treatment options. Subjects in this study will receive one of four intramyocardial doses of XC001 that expresses human vascular endothelial growth factor (VEGF) which induces therapeutic angiogenesis (revascularization).

Coronary Artery DiseaseIschemiaAngina Refractory+2 more

XyloCor Therapeutics, Inc.41 participantsStarted Jan 2020

Stanford, California, United States • Washington D.C., District of Columbia, United States • Daytona Beach, Florida, United States +13 more locations

LEft Bundle branchArea Pacing to Avoid Pacing-induced CARdiomyopathy

Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial)

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