Heart Disease Clinical Trials in San Francisco

Showing 221-240 of 283 trials

Effect of Cocoa Flavanols on Vascular Function

NCT00553774

Endothelial dysfunction is associated with a higher incidence of adverse cardiovascular events in patients with coronary artery disease (CAD). CAD patients also show impaired function and number of endothelial progenitor cells (EPCs, adult stem cells) which circulate in adult blood and contribute to endothelial repair. Clinical studies suggest that endothelial function can be improved in CAD patients by consumption of flavanol-rich cocoa. Yet, the mechanism is not known. It is also not known whether flavanol-rich cocoa provides an additive, positive effect in patients who are already receiving the maximal recommended therapies for risk factor modification. Therefore, the researchers propose to perform an investigator-initiated, randomized controlled cross-over study administering flavanol-rich cocoa or a placebo for two months in CAD patients on optimal medical therapy. An improvement of endothelial function as measured by flow-mediated dilation (FMD) will be the primary endpoint of this study. The researchers propose to also measure determinants of FMD such as microvascular response, inflammatory markers, metabolites of nitric oxide, as well as the number and function of EPCs in the blood. Importantly, detailed food questionnaires and plasma flavanols/metabolites will help to further support a causal link between flavanol-intake and improved vascular function.

Coronary Artery Disease

University of California, San Francisco16 participantsStarted Mar 2007

San Francisco, California, United States

COMPLETEDNA< 1 mile

Better Effectiveness After Transition - Heart Failure

NCT01360203

The purpose of this study is to compare the effect of implementing wireless remote monitoring combined with structured telephone monitoring, versus current care, on variation in rehospitalization among older patients hospitalized with heart failure at six medical centers.

Heart Failure

University of California, Los Angeles1,437 participantsStarted Oct 2011

Davis, California, United States • Irvine, California, United States • Los Angeles, California, United States +3 more locations

Effect of Cocoa Flavanols on Vascular Function

Better Effectiveness After Transition - Heart Failure

Heart Disease Trials in Other Cities

GORE Flow Reversal System and GORE Embolic Filter Extension Study

Does Prophylactic Coronary Artery Revascularization for High Risk Patients Reduce Long-term Risk of Mortality

Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas

RAMP 200 / RAMP Cardiovascular Tests at the Point-of-Care

Relation of Diet to Heart Disease Risk Factors in Children

Effects of High Fruit, Vegetable, and Dairy Intake on Plasma Lipids and Blood Pressure in Healthy Individuals

CardioMetabolic Program Meets eHealth: Redesign and Evaluation for Optimal Reach and Impact

A Phase II Study of the Safety and Efficacy of MPSK3169A in Patients With Coronary Heart Disease or High Risk of Coronary Heart Disease

Assessment of Catheter-based Interrogation and Standard Techniques for Fractional Flow Reserve Measurement

TAXUS Libertē Post Approval Study

Study of the Effect of Sitagliptin on Glucose (Sugar) Metabolism in Patients With Heart Failure

Safety and Efficacy of Mipomersen (ISIS 301012) As Add-on Therapy in High Risk Hypercholesterolemic Patients

Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function

Niacin Plus Statin to Prevent Vascular Events

Efficacy and Safety Study of ISIS 301012 (Mipomersen) as Add-on in Familial Hypercholesterolemic Patients With Coronary Artery Disease

Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients

Improving Clinician Communication Skills (ICCS)

Sensor Optimization of Cardiac Resynchronization Therapy Response

Other Conditions in San Francisco