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Clareo Health | Depression Clinical Trials in Houston | 166 Studies

Clinical Trials DepressionHouston

Depression Clinical Trials in Houston

Find 166 clinical trials for depression near Houston, Texas. Connect with research centers in your area.

All Depression trials nationwide All trials in Houston

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RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

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Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4No phase

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Showing 1-20 of 166 trials

CompletedSafety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive DisorderAn outpatient study to evaluate the safety and efficacy of cariprazine as adjunct to antidepressant therapy (ADT) in participants with major depressive disorder (MDD) who have an…NCT01469377·Garden Grove, California and 71 others

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Data from ClinicalTrials.govTerms

CompletedSafety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)To assess the long-term safety and tolerability of oral OPC-34712 (brexpiprazole), given in addition to an FDA approved antidepressant (ADT) for the treatment of adults with Major…NCT01360866·Birmingham, Alabama and 141 others

CompletedEfficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and DepressionThe primary objective of the study is to evaluate whether armodafinil at a target dosage of 200 mg/day is more effective than placebo treatment in improving excessive sleepiness…NCT00518986·Jasper, Alabama and 61 others

CompletedThe MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD)The MOOD study will evaluate the safety and efficacy of a noninvasive, self-administered external Combined Occipital and Trigeminal Neurostimulation (eCOT-NS) treatment for Major…NCT04279522·La Jolla, California and 12 others

CompletedALTO-100 in MDD and/or PTSDThe goal of this study is to collect biologically based data for defining predictors and correlates of the effects of ALTO-100.NCT05117632·Tempe, Arizona and 22 others

TerminatedA Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic FeaturesApproximately 450 patients will be randomized to receive mifepristone or placebo for 7 days followed by antidepressant.NCT00637494·Little Rock, Arkansas and 41 others

CompletedTo Evaluate the Effects of NMRA-335140 on Symptoms of Major Depression in Participants With Bipolar II Disorder.This is a randomized, double-blind, placebo-controlled pilot study aiming to evaluate the effects of NMRA-335140 on symptoms of major depression in adults with Bipolar (BP) II…NCT06429722·Phoenix, Arizona and 20 others

CompletedA Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD)The purpose of this study is to determine if TC-5214 or placebo (a tablet that looks like medicine tablet or capsule, but contains no active medicine) is safe and effective when…NCT01157078·Tuscaloosa, Alabama and 50 others

TerminatedA Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)The purpose of this study is to assess the long-term safety and tolerability of aticaprant administered as adjunctive therapy to a current antidepressant (selective serotonin…NCT05518149·Birmingham, Alabama and 233 others

RecruitingGamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant DepressionThe core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a…NCT06480201·Houston, Texas and 1 other

RecruitingLong-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD.NCT06966401·Huntsville, Alabama and 105 others

CompletedA Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive DisorderThe primary purpose of this study is to evaluate the efficacy of SAGE-217 plus an ADT in the treatment of major depressive disorder (MDD) compared to placebo plus an ADT.NCT04476030·Dothan, Alabama and 50 others

CompletedEfficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in the Treatment of Major Depressive DisordersThe purpose of this study is to demonstrate superior efficacy of Quetiapine fumarate sustained release (SEROQUEL) compared with placebo when used as a mono-therapy in the…NCT00326144·Phoenix, Arizona and 33 others

Active not recruitingDBS of the Lateral Habenula in Treatment-Resistant DepressionThis research study will investigate the safety, tolerability, and benefit of bilateral deep brain stimulation (DBS) to the lateral habenula in subjects with treatment-resistant…NCT01798407·Houston, Texas

CompletedA Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of SuicideThe purpose of the study is to evaluate the efficacy, safety, and tolerability of SLS-002 (intranasal racemic ketamine) in addition to standard of care on symptoms of Major…NCT04669665·Orange, California and 20 others

CompletedEfficacy and Tolerability of Riluzole in Treatment Resistant DepressionThis study aims to examine the antidepressant efficacy of riluzole, employing a randomized, double-blind, placebo-controlled, adjunctive trial in treatment-resistant major…NCT01204918·New Haven, Connecticut and 2 others

CompletedStudy Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal WomenDesvenlafaxine succinate (DVS) is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI).NCT00406640·Peoria, Arizona and 69 others

TerminatedSafety and Efficacy of EVT 101 in Treatment-Resistant DepressionThis study is a 4-week, randomized, double-blind, parallel-group, placebo-controlled monotherapy study in patients with treatment-resistant major depression.NCT01128452·Oceanside, California and 13 others

CompletedSafety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo and Active Control in Major Depressive DisorderThis study is to evaluate that (SEROQUEL®) quetiapine sustained-release is efficacious and safe in the treatment of patients with MDD.NCT00321490·Birmingham, Alabama and 33 others

CompletedEfficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants AloneThe objective of this study is to evaluate the efficacy, safety and tolerability of cariprazine as an adjunctive treatment to antidepressant therapy (ADT) in patients with MDD who…NCT03738215·Phoenix, Arizona and 124 others

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