Colorectal Cancer Clinical Trials in North Carolina

Showing 21-40 of 303 trials

Ultrasound for the Detection of Oxaliplatin-Induced Peripheral Neuropathy

NCT03958747

This pilot clinical trial studies how well ultrasound works in detecting oxaliplatin-induced neuropathy in participants with gastrointestinal cancer. Ultrasound may work better in diagnosing and detecting neuropathy in gastrointestinal cancer participants treated with the chemotherapy drug called oxaliplatin.

Gastrointestinal CancerColorectal Cancer

Wake Forest University Health Sciences20 participantsStarted Dec 2019

Winston-Salem, North Carolina, United States

COMPLETEDPhase 246 miles

Palbociclib and Cetuximab in Metastatic Colorectal Cancer

NCT03446157

This research study is designed to provide a better understanding of study drugs cetuximab (Erbitux®) and palbociclib when used in combination to treat patients with metastatic colon cancer.

Cancer of the ColonColon CancerColon Neoplasms+2 more

UNC Lineberger Comprehensive Cancer Center24 participantsStarted Mar 2018

Chapel Hill, North Carolina, United States

RECRUITINGPhase 1/257 miles

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

NCT06445062

The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The current subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol C: RMC-6236 + gemcitabine + nab-paclitaxel Subprotocol D: RMC-9805 with or without RMC-6236 + 5-fluorouracil-based regimens Subprotocol E: RMC-9805 with or without RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol F: RMC-9805 with or without RMC-6236 + gemcitabine + nab-paclitaxel

Colorectal CancerCRCPancreatic Ductal Adenocarcinoma+3 more

Revolution Medicines, Inc.1,130 participantsStarted May 2024

Chandler, Arizona, United States • Phoenix, Arizona, United States • Scottsdale, Arizona, United States +29 more locations

Ultrasound for the Detection of Oxaliplatin-Induced Peripheral Neuropathy

Palbociclib and Cetuximab in Metastatic Colorectal Cancer

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Colorectal Cancer Trials in Other Cities

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

ColoSeal™ ICD System Anastomotic Protection Pivotal Study

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Phase II Trial of Lung Chemoemobolization

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

GCC19CART for Patients With Metastatic Colorectal Cancer

Other Conditions in North Carolina