Colorectal Cancer Clinical Trials in Denver

Showing 21-40 of 252 trials

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

NCT04678648

RSC-101 is a Phase 1a/1b clinical trial of RSC-1255 in adult study participants with advanced solid tumor malignancies who are intolerant of existing therapies known to provide clinical benefit, have disease that has progressed after standard therapy, or have previously failed other therapies. The study has two phases. The purpose of Phase 1a (Dose Escalation) is to confirm the appropriate treatment dose and Phase 1b (Dose Expansion) is to characterize the safety and efficacy of RSC-1255.

Advanced Malignant Solid NeoplasmRAS MutationLung Cancer+3 more

RasCal Therapeutics, Inc.134 participantsStarted Mar 2021

Los Angeles, California, United States • Denver, Colorado, United States • Nashville, Tennessee, United States

RECRUITINGPhase 1/2< 1 mile

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT04585750

The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C mutation. The Phase 1 portion of the study will assess the safety, tolerability and preliminary efficacy of multiple dose levels of rezatapopt as monotherapy and in Phase 1b in combination with pembrolizumab.

Advanced Solid TumorAdvanced Malignant NeoplasmMetastatic Cancer+27 more

PMV Pharmaceuticals, Inc300 participantsStarted Oct 2020

Irvine, California, United States • La Jolla, California, United States • Los Angeles, California, United States +73 more locations

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Colorectal Cancer Trials in Other Cities

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

GCC19CART for Patients With Metastatic Colorectal Cancer

Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Improving Care for Rural Patients With Solid Tumors

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

ColoSeal™ ICD System Anastomotic Protection Pivotal Study

A Study of MGC026 in Participants With Advanced Solid Tumors

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot Study

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

Phase II Trial of Lung Chemoemobolization

Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

Other Conditions in Denver